Reactome | SEC24A [ER to Golgi transport vesicle membrane]

SEC24A [ER to Golgi transport vesicle membrane]

Stable Identifier

R-HSA-204022

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ER to Golgi transport vesicle membrane

Synonyms

Protein transport protein Sec24A, S24A_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
      - Budding of COPII coated vesicle (Homo sapiens)
        
        COPII vesicle with MHC class I [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Disassembly of COPII coated vesicle (Homo sapiens)
        
        COPII [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII vesicle with MHC class I [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24A [ER to Golgi transport vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95486 SEC24A

Gene Names

SEC24A

Chain

chain:1-1093

Reference Genes

BioGPS Gene:10802 SEC24A

COSMIC (genes):SEC24A SEC24A

CTD Gene:10802 SEC24A

dbSNP Gene:10802 SEC24A

ENSEMBL:ENSG00000113615 SEC24A

ENSEMBL_homo_sapiens_GENE:ENSG00000113615.13 SEC24A

HGNC:10703 SEC24A

KEGG Gene (Homo sapiens):10802 SEC24A

Monarch:10802 SEC24A

NCBI Gene:10802 SEC24A

OMIM:607183 SEC24A

UCSC:O95486 SEC24A

Reference Transcript

Other Identifiers

10802

11743926_a_at

11743927_at

11757836_s_at

11759728_at

16989293

212900_PM_at

212900_at

212902_PM_at

212902_at

244841_PM_at

244841_at

2829417

2829418

2829419

2829420

2829421

2829423

2829424

2829425

2829426

2829427

2829428

2829429

2829431

2829432

2829434

2829435

2829436

2829437

2829438

2829440

2829441

2829442

2829443

2829445

2829446

2829448

2829449

2829450

2829453

2829455

2829457

2829460

2829461

2829462

34199_at

78591_at

8108099

A_14_P108339

A_23_P329593

A_23_P394605

A_33_P3331080

A_33_P3331085

GE507710

GE61763

GO:0000149

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006886

GO:0006888

GO:0008270

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0030127

GO:0031410

GO:0032374

GO:0042632

GO:0043226

GO:0046872

GO:0050714

GO:0061024

GO:0070971

GO:0090110

HMNXSV003044643

HMNXSV003047719

Hs.134218.0.A1_3p_at

Hs.211612.0.S1_3p_at

Hs.211612.0.S2_3p_at

ILMN_2126832

PH_hs_0012278

PH_hs_0041056

TC05000665.hg

Participates

as a member of

SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Other forms of this molecule

SEC24A [endoplasmic reticulum membrane]

SEC24A [cytosol]

p-SEC24A [cytosol]

Inferred To

Sec24AB [ER to Golgi transport vesicle membrane] (Drosophila melanogaster)

sec24a [ER to Golgi transport vesicle membrane] (Xenopus tropicalis)

SEC24A [ER to Golgi transport vesicle membrane] (Bos taurus)

SEC24A [ER to Golgi transport vesicle membrane] (Canis familiaris)

SEC24A [ER to Golgi transport vesicle membrane] (Dictyostelium discoideum)

SEC24A [ER to Golgi transport vesicle membrane] (Gallus gallus)

SEC24A [ER to Golgi transport vesicle membrane] (Mus musculus)

SEC24A [ER to Golgi transport vesicle membrane] (Plasmodium falciparum)

SEC24A [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)

SEC24A [ER to Golgi transport vesicle membrane] (Schizosaccharomyces pombe)

SEC24A [ER to Golgi transport vesicle membrane] (Sus scrofa)

Sec24a [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

sec-24.2 [ER to Golgi transport vesicle membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001239160.1, NP_068817.1

OpenTargets

ENSG00000113615

HPA

ENSG00000113615-SEC24A

GeneCards

O95486

Ensembl

ENSP00000321749, ENSP00000381823, ENST00000322887, ENSG00000113615, ENST00000398844

PRO

O95486

Pharos - Targets

O95486

PDB

5VNO, 5VNH, 5VNJ, 5VNE, 5VNK, 3EGX, 5VNI, 5VNL, 2NUP, 5VNM, 8HR0, 3EGD, 5VNF, 2NUT, 5VNN, 5VNG

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15436 SEC23A	4	p-S738,T744 SEC23A [cytosol] (R-HSA-5685740) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) SEC23A [cytosol] (R-HSA-203972) SEC23A [endoplasmic reticulum membrane] (R-HSA-203976)	0.527	3

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