Reactome | SEC24B [ER to Golgi transport vesicle membrane]

SEC24B [ER to Golgi transport vesicle membrane]

Stable Identifier

R-HSA-204021

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ER to Golgi transport vesicle membrane

Synonyms

Protein transport protein Sec24B, S24B_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen Presentation: Folding, assembly and peptide loading of class I MHC (Homo sapiens)
      - Budding of COPII coated vesicle (Homo sapiens)
        
        COPII vesicle with MHC class I [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Disassembly of COPII coated vesicle (Homo sapiens)
        
        COPII [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII vesicle with MHC class I [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - COPII coat binds TRAPPCII and RAB1:GDP (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - CSNK1D phosphorylates SEC23 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Nucleotide exchange on RAB1 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)
      - Vesicle budding (Homo sapiens)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC23:SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)
        
        SEC24B [ER to Golgi transport vesicle membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95487 SEC24B

Gene Names

SEC24B

Chain

initiator methionine:, chain:2-1268

Reference Genes

BioGPS Gene:10427 SEC24B

COSMIC (genes):SEC24B SEC24B

CTD Gene:10427 SEC24B

dbSNP Gene:10427 SEC24B

ENSEMBL:ENSG00000138802 SEC24B

HGNC:10704 SEC24B

KEGG:hsa:10427 SEC24B

Monarch:10427 SEC24B

NCBI Gene:10427 SEC24B

OMIM:607184 SEC24B

UCSC:O95487 SEC24B

Reference Transcript

Other Identifiers

10427

11716597_a_at

11749637_a_at

16969658

202798_PM_at

202798_at

2739094

2739095

2739101

2739102

2739103

2739107

2739108

2739113

2739115

2739117

2739118

2739126

2739128

2739129

2739130

2739131

2739132

2739133

2739134

2739137

2739138

2739139

2739140

2739143

2739144

2739145

2739146

2739149

2739150

2739151

2739152

2739153

2739155

2739157

35845_at

8096781

A_14_P118064

A_14_P136094

A_23_P69683

GE55216

GO:0000149

GO:0001843

GO:0002093

GO:0003151

GO:0005515

GO:0005737

GO:0005783

GO:0005789

GO:0005829

GO:0006886

GO:0006888

GO:0008270

GO:0012507

GO:0015031

GO:0016020

GO:0016192

GO:0021747

GO:0030127

GO:0030134

GO:0031410

GO:0035909

GO:0043226

GO:0046872

GO:0048856

GO:0060088

GO:0060425

GO:0060463

GO:0060982

GO:0061156

GO:0070971

GO:0072359

GO:0090110

GO:0090178

GO:1901301

HMNXSV003016552

ILMN_1662707

ILMN_1730232

ILMN_1735148

ILMN_1745469

ILMN_2334303

PH_hs_0000744

TC04000562.hg

g5454045_3p_s_at

Participates

as a member of

SEC24 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Other forms of this molecule

p-SEC24B [cytosol]

SEC24B [cytosol]

SEC24B [endoplasmic reticulum membrane]

Inferred To

SFB2 [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)

sec24b [ER to Golgi transport vesicle membrane] (Xenopus tropicalis)

Homologues of SEC24B [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)

SEC24B [ER to Golgi transport vesicle membrane] (Bos taurus)

SEC24B [ER to Golgi transport vesicle membrane] (Canis familiaris)

SEC24B [ER to Golgi transport vesicle membrane] (Dictyostelium discoideum)

SEC24B [ER to Golgi transport vesicle membrane] (Gallus gallus)

SEC24B [ER to Golgi transport vesicle membrane] (Plasmodium falciparum)

SEC24B [ER to Golgi transport vesicle membrane] (Saccharomyces cerevisiae)

SEC24B [ER to Golgi transport vesicle membrane] (Schizosaccharomyces pombe)

SEC24B [ER to Golgi transport vesicle membrane] (Sus scrofa)

Sec24AB [ER to Golgi transport vesicle membrane] (Drosophila melanogaster)

Sec24b [ER to Golgi transport vesicle membrane] (Mus musculus)

Sec24b [ER to Golgi transport vesicle membrane] (Rattus norvegicus)

sec-24.2 [ER to Golgi transport vesicle membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001305015.1, NP_001305014.1, NP_006314.2, NP_001287742.1, NP_001036199.1

ENSEMBL

ENST00000504968, ENST00000265175, ENST00000399100, ENSP00000428564, ENSP00000382051, ENSP00000265175

OpenTargets

ENSG00000138802

HPA

ENSG00000138802-SEC24B

PRO

O95487

Pharos - Targets

O95487

GlyGen

O95487

PDB

3EH1

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15436 SEC23A	4	SEC23A [endoplasmic reticulum membrane] (R-HSA-203976) SEC23A [cytosol] (R-HSA-203972) SEC23A [ER to Golgi transport vesicle membrane] (R-HSA-204024) p-S738,T744 SEC23A [cytosol] (R-HSA-5685740)	0.669	4

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