Microprocessor complex cleaves pri-miRNA to pre-miRNA

Stable Identifier
R-HSA-203893
Type
Reaction [transition]
Species
Homo sapiens
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Nuclear processing by Drosha Microprocessor complex. The primary-microRNA (pri-miRNA) is recognized by the Microprocessor complex (Drosha:DGCR8) and both strands of the pri-miRNA are cleaved by Drosha near the free 5' and 3' ends of the pri-miRNA, that is, at the ends distal from the internal loop. The product is a double-stranded RNA having 2 nucleotides protruding at the 3' end and having an internal loop.

Literature References
PubMed ID Title Journal Year
15531877 The Microprocessor complex mediates the genesis of microRNAs

Gregory, RI, Yan, KP, Amuthan, G, Doratotaj, B, Cooch, N, Shiekhattar, R, Chendrimada, TP

Nature 2004
25326327 Global identification of target recognition and cleavage by the Microprocessor in human ES cells

Seong, Y, Lim, DH, Kim, A, Seo, JH, Lee, YS, Song, H, Kwon, YS

Nucleic Acids Res. 2014
15574589 The Drosha-DGCR8 complex in primary microRNA processing

Han, J, Lee, Y, Yeom, KH, Kim, YK, Jin, H, Kim, VN

Genes Dev 2004
14508493 The nuclear RNase III Drosha initiates microRNA processing

Lee, Y, Ahn, C, Han, J, Choi, H, Kim, J, Yim, J, Lee, J, Provost, P, Radmark, O, Kim, S, Kim, VN

Nature 2003
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Catalyst Activity
Title
ribonuclease III activity of MicroProcessor Complex [nucleoplasm]
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