Reactome | eNOS:NOSIP translocation from caveolae to intracellular compartments

eNOS:NOSIP translocation from caveolae to intracellular compartments

Stable Identifier

R-HSA-203680

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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eNOS:NOSIP translocation from caveolae to intracellular compartments

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NOSIP promotes translocation of eNOS from the plasma membrane to intracellular sites, thereby uncoupling eNOS from plasma membrane caveolae and inhibiting NO synthesis. eNOS appears to be shifted to intracellular sites that colocalize with Golgi and/or cytoskeletal marker proteins.

Literature References

PubMed ID	Title	Journal	Year
11149895	NOSIP, a novel modulator of endothelial nitric oxide synthase activity Dedio, J, Konig, P, Wohlfart, P, Schroeder, C, Kummer, W, Muller-Esterl, W	FASEB J	2001
12446846	NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase Zimmermann, K, Opitz, N, Dedio, J, Renne, C, Muller-Esterl, W, Oess, S	Proc Natl Acad Sci U S A	2002