eNOS:NOSIP translocation from caveolae to intracellular compartments

Stable Identifier
R-HSA-203680
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

NOSIP promotes translocation of eNOS from the plasma membrane to intracellular sites, thereby uncoupling eNOS from plasma membrane caveolae and inhibiting NO synthesis. eNOS appears to be shifted to intracellular sites that colocalize with Golgi and/or cytoskeletal marker proteins.

Literature References
PubMed ID Title Journal Year
12446846 NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase

Zimmermann, K, Opitz, N, Dedio, J, Renne, C, Muller-Esterl, W, Oess, S

Proc Natl Acad Sci U S A 2002
11149895 NOSIP, a novel modulator of endothelial nitric oxide synthase activity

Dedio, J, Konig, P, Wohlfart, P, Schroeder, C, Kummer, W, Muller-Esterl, W

FASEB J 2001
Participants
Participant Of
Orthologous Events
Reviewed
Created