NOSIP mediated eNOS trafficking

Stable Identifier
R-HSA-203754
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this pathway in the Pathway Browser

eNOS-interacting protein (NOSIP) is a 34-kDa nucleocytoplasmic shuttling protein that binds to the COOH-terminal region (amino acids 366-486) of the eNOS oxygenase domain. This protein association promotes translocation of eNOS from the plasma membrane caveolae to the cytoskeleton and inhibits eNOS activity. Studies have found that NOSIP accumulates in the cytoplasm specifically during the G2 phase of the cell cycle.

Literature References
PubMed ID Title Journal Year
16722822 Subcellular targeting and trafficking of nitric oxide synthases

Oess, S, Icking, A, Fulton, D, Govers, R, Muller-Esterl, W

Biochem J 2006
16234328 NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS

Icking, A, Matt, S, Opitz, N, Wiesenthal, A, Muller-Esterl, W, Schilling, K

J Cell Sci 2005
12842859 Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide

Kone, BC, Kuncewicz, T, Zhang, W, Yu, ZY

Am J Physiol Renal Physiol 2003
Participants
Participant Of
Event Information
Orthologous Events
Reviewed
Created