Reactome | NOSTRIN mediated eNOS trafficking

NOSTRIN mediated eNOS trafficking

Stable Identifier

R-HSA-203641

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

eNOS traffic inducer (NOSTRIN) is a novel 506-amino acid eNOS-interacting protein. Along with a decrease in eNOS activity, NOSTRIN causes translocation of eNOS from the plasma membrane to intracellular vesicular structures. NOSTRIN functions as an adaptor protein through homotrimerization and recruitment of eNOS, dynamin-2, and N-WASP to its SH3 domain. Studies indicated that NOSTRIN may facilitate vesicle fission and endocytosis of eNOS by coordinating the function of dynamin and N-WASP, which in turn, recruits the Arp2/3 complex, initiating actin filament polymerization. Overall, this process is thought to occur via caveolar endocytosis.

Literature References

PubMed ID	Title	Journal	Year
12446846	NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase Zimmermann, K, Opitz, N, Dedio, J, Renne, C, Muller-Esterl, W, Oess, S	Proc Natl Acad Sci U S A	2002
16234328	NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS Icking, A, Matt, S, Opitz, N, Wiesenthal, A, Muller-Esterl, W, Schilling, K	J Cell Sci	2005
16722822	Subcellular targeting and trafficking of nitric oxide synthases Oess, S, Icking, A, Fulton, D, Govers, R, Muller-Esterl, W	Biochem J	2006
12842859	Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide Kone, BC, Kuncewicz, T, Zhang, W, Yu, ZY	Am J Physiol Renal Physiol	2003