NOSTRIN mediated eNOS trafficking

Stable Identifier
R-HSA-203641
Type
Pathway
Species
Homo sapiens
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eNOS traffic inducer (NOSTRIN) is a novel 506-amino acid eNOS-interacting protein. Along with a decrease in eNOS activity, NOSTRIN causes translocation of eNOS from the plasma membrane to intracellular vesicular structures. NOSTRIN functions as an adaptor protein through homotrimerization and recruitment of eNOS, dynamin-2, and N-WASP to its SH3 domain. Studies indicated that NOSTRIN may facilitate vesicle fission and endocytosis of eNOS by coordinating the function of dynamin and N-WASP, which in turn, recruits the Arp2/3 complex, initiating actin filament polymerization. Overall, this process is thought to occur via caveolar endocytosis.



Literature References
PubMed ID Title Journal Year
12446846 NOSTRIN: a protein modulating nitric oxide release and subcellular distribution of endothelial nitric oxide synthase

Renne, C, Muller-Esterl, W, Oess, S, Opitz, N, Dedio, J, Zimmermann, K

Proc Natl Acad Sci U S A 2002
16234328 NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS

Muller-Esterl, W, Opitz, N, Wiesenthal, A, Schilling, K, Icking, A, Matt, S

J Cell Sci 2005
16722822 Subcellular targeting and trafficking of nitric oxide synthases

Muller-Esterl, W, Fulton, D, Oess, S, Govers, R, Icking, A

Biochem J 2006
12842859 Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide

Yu, ZY, Zhang, W, Kone, BC, Kuncewicz, T

Am J Physiol Renal Physiol 2003
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