eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP

Stable Identifier
R-HSA-203565
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
NOSTRIN interacts with the actin nucleation promoting factor N-WASP by means of its SH3 domain.
Literature References
PubMed ID Title Journal Year
16807357 Translocation of endothelial nitric-oxide synthase involves a ternary complex with caveolin-1 and NOSTRIN

Schilling, K, Opitz, N, Wiesenthal, A, Oess, S, Tikkanen, R, Muller-Esterl, W, Icking, A

Mol Biol Cell 2006
16234328 NOSTRIN functions as a homotrimeric adaptor protein facilitating internalization of eNOS

Icking, A, Matt, S, Opitz, N, Wiesenthal, A, Muller-Esterl, W, Schilling, K

J Cell Sci 2005
16722822 Subcellular targeting and trafficking of nitric oxide synthases

Oess, S, Icking, A, Fulton, D, Govers, R, Muller-Esterl, W

Biochem J 2006
Participants
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Output
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as an event of
Catalyst Activity

cargo adaptor activity of eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane]

Physical Entity
eNOS:Caveolin-1:NOSTRIN:Dynamin-2 [plasma membrane] (Homo sapiens)
Activity
cargo adaptor activity (GO:0140312)
Orthologous Events
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Bos taurus)
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Canis familiaris)
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Danio rerio)
eNOS:Caveolin-1:NOSTRIN:dynamin-2 complex binds N-WASP (Sus scrofa)
Reviewed
Enikolopov, G  (2008-02-28)
Hill, DP  (2024-08-02)
Created
Hemish, J  (2007-10-19)
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