Caspase mediated cleavage of HIP-55

Stable Identifier
R-HSA-202966
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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HIP-55 is an actin binding SH3 domain protein that is cleaved by caspase-3. Cleavage results in dissociation of the actin-binding domain from the SH3 domain and may alter cell signaling to and from the actin cytoskeleton. In addition, this cleavage may be involved in the the alteration in cell morphology that occur during apoptosis (Chen et al., 2001).

Literature References
PubMed ID Title Journal Year
11689006 Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis

Chen, YR, Kori, R, John, B, Tan, TH

Biochem Biophys Res Commun 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created