Reactome | Caspase mediated cleavage of HIP-55

Caspase mediated cleavage of HIP-55

Stable Identifier

R-HSA-202966

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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HIP-55 is an actin binding SH3 domain protein that is cleaved by caspase-3. Cleavage results in dissociation of the actin-binding domain from the SH3 domain and may alter cell signaling to and from the actin cytoskeleton. In addition, this cleavage may be involved in the the alteration in cell morphology that occur during apoptosis (Chen et al., 2001).

Literature References

PubMed ID	Title	Journal	Year
11689006	Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis Chen, YR, Kori, R, John, B, Tan, TH	Biochem Biophys Res Commun	2001