Caspase mediated cleavage of HIP-55

Stable Identifier
R-HSA-202966
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Caspase mediated cleavage of HIP-55
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HIP-55 is an actin binding SH3 domain protein that is cleaved by caspase-3. Cleavage results in dissociation of the actin-binding domain from the SH3 domain and may alter cell signaling to and from the actin cytoskeleton. In addition, this cleavage may be involved in the the alteration in cell morphology that occur during apoptosis (Chen et al., 2001).

Literature References
PubMed ID Title Journal Year
11689006 Caspase-mediated cleavage of actin-binding and SH3-domain-containing proteins cortactin, HS1, and HIP-55 during apoptosis

Chen, YR, Kori, R, John, B, Tan, TH

Biochem Biophys Res Commun 2001
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Caspase-3 [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
Orthologous Events
Caspase mediated cleavage of HIP-55 (Canis familiaris)
Caspase mediated cleavage of HIP-55 (Danio rerio)
Caspase mediated cleavage of HIP-55 (Drosophila melanogaster)
Caspase mediated cleavage of HIP-55 (Gallus gallus)
Caspase mediated cleavage of HIP-55 (Mus musculus)
Caspase mediated cleavage of HIP-55 (Rattus norvegicus)
Caspase mediated cleavage of HIP-55 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2007-09-03)
Reviewed
Ranganathan, S  (2007-11-23)
Created
Matthews, L  (2007-11-12)