YWHAE (14-3-3 epsilon) binds phosphorylated WWTR1 (TAZ), sequestering it in the cytosol. Structural studies indicate that the active form of YWHAE (14-3-3 epsilon) is a homodimer (Yang et al. 2006); the stoichiometry of its complex with WWTR1 (TAZ) is unknown and has been annotated arbitrarily here to involve one WWTR1 (TAZ) molecule and a YWHAE(14-3-3 epsilon) dimer. Phosphorylation of serine residue 127 of WWTR1 (TAZ) appears to be critical for YWHAE (14-3-3 epsilon) binding (Kanai et al. 2000; Lei et al. 2008).
Elkins, JM, Sobott, F, Papagrigoriou, E, Grossmann, JG, Robinson, CV, Sundström, M, Lee, WH, Yang, X, Doyle, DA
Lei, Q, Guan, KL, Xiong, Y, Pei, XH, Zhang, H, Zha, ZY, Zhao, B, Bai, F, Zhao, S
Ito, Y, Hall, RA, Cantley, LC, Yagi, R, Marignani, PA, Hisaminato, A, Donowitz, M, Yaffe, MB, Fujiwara, T, Sarbassova, D, Kanai, F
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