YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)

Stable Identifier
R-HSA-2028651
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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YWHAE (14-3-3 epsilon) binds phosphorylated WWTR1 (TAZ), sequestering it in the cytosol. Structural studies indicate that the active form of YWHAE (14-3-3 epsilon) is a homodimer (Yang et al. 2006); the stoichiometry of its complex with WWTR1 (TAZ) is unknown and has been annotated arbitrarily here to involve one WWTR1 (TAZ) molecule and a YWHAE(14-3-3 epsilon) dimer. Phosphorylation of serine residue 127 of WWTR1 (TAZ) appears to be critical for YWHAE (14-3-3 epsilon) binding (Kanai et al. 2000; Lei et al. 2008).

Literature References
PubMed ID Title Journal Year
18227151 TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

Lei, Q, Zhang, H, Zhao, B, Zha, ZY, Bai, F, Pei, XH, Zhao, S, Xiong, Y, Guan, KL

Mol Cell Biol 2008
17085597 Structural basis for protein-protein interactions in the 14-3-3 protein family

Yang, X, Lee, WH, Sobott, F, Papagrigoriou, E, Robinson, CV, Grossmann, JG, Sundström, M, Doyle, DA, Elkins, JM

Proc Natl Acad Sci U S A 2006
11118213 TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

Kanai, F, Marignani, PA, Sarbassova, D, Yagi, R, Hall, RA, Donowitz, M, Hisaminato, A, Fujiwara, T, Ito, Y, Cantley, LC, Yaffe, MB

EMBO J 2000
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