Reactome | YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)

YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)

Stable Identifier

R-HSA-2028651

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)

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YWHAE (14-3-3 epsilon) binds phosphorylated WWTR1 (TAZ), sequestering it in the cytosol. Structural studies indicate that the active form of YWHAE (14-3-3 epsilon) is a homodimer (Yang et al. 2006); the stoichiometry of its complex with WWTR1 (TAZ) is unknown and has been annotated arbitrarily here to involve one WWTR1 (TAZ) molecule and a YWHAE(14-3-3 epsilon) dimer. Phosphorylation of serine residue 127 of WWTR1 (TAZ) appears to be critical for YWHAE (14-3-3 epsilon) binding (Kanai et al. 2000; Lei et al. 2008).

Literature References

PubMed ID	Title	Journal	Year
17085597	Structural basis for protein-protein interactions in the 14-3-3 protein family Yang, X, Lee, WH, Sobott, F, Papagrigoriou, E, Robinson, CV, Grossmann, JG, Sundström, M, Doyle, DA, Elkins, JM	Proc Natl Acad Sci U S A	2006
18227151	TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway Lei, Q, Zhang, H, Zhao, B, Zha, ZY, Bai, F, Pei, XH, Zhao, S, Xiong, Y, Guan, KL	Mol Cell Biol	2008
11118213	TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins Kanai, F, Marignani, PA, Sarbassova, D, Yagi, R, Hall, RA, Donowitz, M, Hisaminato, A, Fujiwara, T, Ito, Y, Cantley, LC, Yaffe, MB	EMBO J	2000