YWHAE (14-3-3 epsilon) dimer binds phosphorylated WWTR1 (TAZ)

Stable Identifier
Reaction [binding]
Homo sapiens
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YWHAE (14-3-3 epsilon) binds phosphorylated WWTR1 (TAZ), sequestering it in the cytosol. Structural studies indicate that the active form of YWHAE (14-3-3 epsilon) is a homodimer (Yang et al. 2006); the stoichiometry of its complex with WWTR1 (TAZ) is unknown and has been annotated arbitrarily here to involve one WWTR1 (TAZ) molecule and a YWHAE(14-3-3 epsilon) dimer. Phosphorylation of serine residue 127 of WWTR1 (TAZ) appears to be critical for YWHAE (14-3-3 epsilon) binding (Kanai et al. 2000; Lei et al. 2008).

Literature References
PubMed ID Title Journal Year
17085597 Structural basis for protein-protein interactions in the 14-3-3 protein family

Elkins, JM, Sobott, F, Papagrigoriou, E, Grossmann, JG, Robinson, CV, Sundström, M, Lee, WH, Yang, X, Doyle, DA

Proc Natl Acad Sci U S A 2006
18227151 TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway

Lei, Q, Guan, KL, Xiong, Y, Pei, XH, Zhang, H, Zha, ZY, Zhao, B, Bai, F, Zhao, S

Mol Cell Biol 2008
11118213 TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

Ito, Y, Hall, RA, Cantley, LC, Yagi, R, Marignani, PA, Hisaminato, A, Donowitz, M, Yaffe, MB, Fujiwara, T, Sarbassova, D, Kanai, F

EMBO J 2000
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