Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)

Stable Identifier
R-HSA-2028294
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Mast Cell Carboxypeptidase Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)
ReviewStatus
5/5
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Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)
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Mast cell carboxypeptidase (CPA3) hydrolyzes a single amino acid residue from the C-terminus of angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9).

Literature References
PubMed ID Title Journal Year
2708524 Human mast cell carboxypeptidase. Purification and characterization

Goldstein, SM, Kaempfer, CE, Kealey, JT, Wintroub, BU

J Clin Invest 1989
2443571 Detection and partial characterization of a human mast cell carboxypeptidase

Irani, AM, Schwartz, LB, Proud, D, Goldstein, SM, Kaempfer, CE, Wintroub, BU

J Immunol 1987
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
angiotensin maturation (0002003)
Catalyst Activity

metallocarboxypeptidase activity of Carboxypeptidase [extracellular region]

Physical Entity
Carboxypeptidase [extracellular region] (Homo sapiens)
Activity
metallocarboxypeptidase activity (GO:0004181)
Orthologous Events
Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Bos taurus)
Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Canis familiaris)
Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Danio rerio)
Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Mus musculus)
Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Rattus norvegicus)
Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9) (Xenopus tropicalis)
Authored
May, B  (2011-12-23)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-12-28)
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