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Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
Stable Identifier
R-HSA-202266
Type
Complex
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Change of PKC theta conformation (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Activation of Lck (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
Inactivation of LCK by PTPN22 (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Phosphorylation of ZAP-70 by Lck (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
Participants
components
CD4 [plasma membrane]
(Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane]
(Homo sapiens)
p-Y394-LCK [cytosol]
(Homo sapiens)
T-cell receptor complex [plasma membrane]
(Homo sapiens)
Participates
as an input of
Inactivation of LCK by PTPN22 (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
as an output of
Activation of Lck (Homo sapiens)
Inferred To
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
(Bos taurus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
(Canis familiaris)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
(Gallus gallus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
(Mus musculus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
(Rattus norvegicus)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
(Sus scrofa)
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