Neprilysin (MME aka neutral endopeptidase NEP) hydrolyzes angiotensin-(1-10) (AGT(34-43), angiotensin I) directly to angiotensin-(1-7) (Rice et al. 2004). MME is the major enzyme involved in the metabolic inactivation of a number of bioactive signaling peptides including the enkephalins, substance P, endothelin, bradykinin, atrial natriuretic factor, and the incretin hormone glucagon-like peptide 1. MME requires zinc as cofactor (Oefner et al. 2004, Oefner et al. 2007).