Reactome | ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))

ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))

Stable Identifier

R-HSA-2022378

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

ACE2(18-805):Zn2+ Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)

ReviewStatus

5/5

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ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9))

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Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9) (Donoghue et al. 2000, Tipnis et al. 2000, Vickers et al. 2002, Rice t al. 2004). The activity of ACE2 on angiotensin I is weak (Rice et al. 2004), being 400-fold lower than the activity of ACE2 on angiotensin II (Vickers et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11815627	Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase Vickers, C, Hales, P, Kaushik, V, Dick, L, Gavin, J, Tang, J, Godbout, K, Parsons, T, Baronas, E, Hsieh, F, Acton, S, Patane, M, Nichols, A, Tummino, P	J Biol Chem	2002
15283675	Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism Rice, GI, Thomas, DA, Grant, PJ, Turner, AJ, Hooper, NM	Biochem J	2004
10924499	A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase Tipnis, SR, Hooper, NM, Hyde, R, Karran, E, Christie, G, Turner, AJ	J Biol Chem	2000
10969042	A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 Donoghue, M, Hsieh, F, Baronas, E, Godbout, K, Gosselin, M, Stagliano, N, Donovan, M, Woolf, B, Robison, K, Jeyaseelan, R, Breitbart, RE, Acton, S	Circ Res	2000