ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)

Stable Identifier
R-HSA-2022378
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
ACE2 Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9) (Donoghue et al. 2000, Tipnis et al. 2000, Vickers et al. 2002, Rice t al. 2004). The activity of ACE2 on angiotensin I is weak (Rice et al. 2004), being 400-fold lower than the activity of ACE2 on angiotensin II (Vickers et al. 2002).

Literature References
PubMed ID Title Journal Year
15283675 Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

Rice, GI, Thomas, DA, Grant, PJ, Turner, AJ, Hooper, NM

Biochem J 2004
11815627 Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

Vickers, C, Hales, P, Kaushik, V, Dick, L, Gavin, J, Tang, J, Godbout, K, Parsons, T, Baronas, E, Hsieh, F, Acton, S, Patane, M, Nichols, A, Tummino, P

J Biol Chem 2002
10924499 A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

Tipnis, SR, Hooper, NM, Hyde, R, Karran, E, Christie, G, Turner, AJ

J Biol Chem 2000
10969042 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

Donoghue, M, Hsieh, F, Baronas, E, Godbout, K, Gosselin, M, Stagliano, N, Donovan, M, Woolf, B, Robison, K, Jeyaseelan, R, Breitbart, RE, Acton, S

Circ Res 2000
Participants
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
Title
metallocarboxypeptidase activity of ACE2(18-805) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
Cite Us!