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LRP5/6 [plasma membrane]
Stable Identifier
R-HSA-201719
Type
Set [CandidateSet]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by RNF43 mutants (Homo sapiens)
RNF43 frameshift mutants show enhanced WNT siganling (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
FZD recruits DVL to the receptor complex (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6:DVL [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
Negative regulation of TCF-dependent signaling by WNT ligand antagonists (Homo sapiens)
DKK and KRM bind LRP5/6 (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
DKK promotes clathrin-dependent internalization of LRP6 (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
SOST binds LRP5/6 (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
SOST:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
Regulation of FZD by ubiquitination (Homo sapiens)
USP8 deubiquitinates FZD to potentiate WNT signaling (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
ZNRF3 ubiquitinates FZD to promote its downregulation (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
ZNRF3,RNF43 binds the FZD:LRP5/6 receptor complex (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
WNT binds to FZD and LRP5/6 (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
SOST:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
LRP5/6 [plasma membrane] (Homo sapiens)
Participants
members
LRP6 [plasma membrane]
(Homo sapiens)
candidates
LRP5 [plasma membrane]
(Homo sapiens)
Participates
as an input of
SOST binds LRP5/6 (Homo sapiens)
DKK and KRM bind LRP5/6 (Homo sapiens)
WNT binds to FZD and LRP5/6 (Homo sapiens)
as a component of
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6:ZNRF3/RNF43 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
N4GlycoAsn-PalmS-WNT3A:ub-FZD:LRP5/6 [plasma membrane] (Homo sapiens)
SOST:LRP5/6 [plasma membrane] (Homo sapiens)
KRM:DKK:LRP5/6 [plasma membrane] (Homo sapiens)
WNT:FZD:LRP5/6 [plasma membrane] (Homo sapiens)
Inferred To
LRP6 [plasma membrane]
(Gallus gallus)
LRP5/6 [plasma membrane]
(Bos taurus)
LRP5/6 [plasma membrane]
(Caenorhabditis elegans)
LRP5/6 [plasma membrane]
(Canis familiaris)
LRP5/6 [plasma membrane]
(Danio rerio)
LRP5/6 [plasma membrane]
(Drosophila melanogaster)
LRP5/6 [plasma membrane]
(Mus musculus)
LRP5/6 [plasma membrane]
(Rattus norvegicus)
LRP5/6 [plasma membrane]
(Sus scrofa)
LRP5/6 [plasma membrane]
(Xenopus tropicalis)
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