Caspase-mediated cleavage of plectin-1

Stable Identifier
R-HSA-201637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Caspase-mediated cleavage of plectin-1
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Plectin is a major cross-linking protein of the three main cytoplasmic filament systems. Caspase-8 mediated cleavage of plectin 1 appears to contribute to disruption of the microfilament system during the early stages of apoptosis (Stegh et al., 2000).

Literature References
PubMed ID Title Journal Year
10891503 Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis

Wiche, G, Stegh, AH, Seper, M, Lampel, S, Herrmann, H, Andrä, K, Peter, ME, Weisenberger, D, Krammer, PH

Mol Cell Biol 2000
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Catalyst Activity

cysteine-type endopeptidase activity of active caspase-8 [cytosol]

Physical Entity
active caspase-8 [cytosol] (Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Orthologous Events
Caspase-mediated cleavage of plectin-1 (Bos taurus)
Caspase-mediated cleavage of plectin-1 (Canis familiaris)
Caspase-mediated cleavage of plectin-1 (Danio rerio)
Caspase-mediated cleavage of plectin-1 (Mus musculus)
Caspase-mediated cleavage of plectin-1 (Rattus norvegicus)
Caspase-mediated cleavage of plectin-1 (Sus scrofa)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-12)
Created
Matthews, L  (2007-09-03)
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