Caspase-mediated cleavage of plectin-1

Stable Identifier
R-HSA-201637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Plectin is a major cross-linking protein of the three main cytoplasmic filament systems. Caspase-8 mediated cleavage of plectin 1 appears to contribute to disruption of the microfilament system during the early stages of apoptosis (Stegh et al., 2000).

Literature References
PubMed ID Title Journal Year
10891503 Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis

Stegh, AH, Herrmann, H, Lampel, S, Weisenberger, D, Andrä, K, Seper, M, Wiche, G, Krammer, PH, Peter, ME

Mol Cell Biol 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-8 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created