Plectin is a major cross-linking protein of the three main cytoplasmic filament systems. Caspase-8 mediated cleavage of plectin 1 appears to contribute to disruption of the microfilament system during the early stages of apoptosis (Stegh et al., 2000).
Wiche, G, Stegh, AH, Seper, M, Lampel, S, Herrmann, H, Andrä, K, Peter, ME, Weisenberger, D, Krammer, PH
cysteine-type endopeptidase activity of active caspase-8 [cytosol]
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