Caspase-mediated cleavage of Tau

Stable Identifier
R-HSA-201629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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Caspase-mediated cleavage of Tau
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Caspase-3 cleaves Tau at position 421 in vitro producing an N-terminal fragment that functions as an apoptotic effector (Fasulo et al., 2000).

Literature References
PubMed ID Title Journal Year
10899937 The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

Fasulo, L, Ugolini, G, Visintin, M, Bradbury, A, Brancolini, C, Verzillo, V, Novak, M, Cattaneo, A

J Neurochem 2000
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Caspase-3 [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
Orthologous Events
Caspase-mediated cleavage of Tau (Canis familiaris)
Caspase-mediated cleavage of Tau (Danio rerio)
Caspase-mediated cleavage of Tau (Drosophila melanogaster)
Caspase-mediated cleavage of Tau (Gallus gallus)
Caspase-mediated cleavage of Tau (Mus musculus)
Caspase-mediated cleavage of Tau (Rattus norvegicus)
Caspase-mediated cleavage of Tau (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2007-09-03)