Caspase-mediated cleavage of Tau

Stable Identifier
R-HSA-201629
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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General
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Caspase-3 cleaves Tau at position 421 in vitro producing an N-terminal fragment that functions as an apoptotic effector (Fasulo et al., 2000).

Literature References
PubMed ID Title Journal Year
10899937 The neuronal microtubule-associated protein tau is a substrate for caspase-3 and an effector of apoptosis

Fasulo, L, Ugolini, G, Visintin, M, Bradbury, A, Brancolini, C, Verzillo, V, Novak, M, Cattaneo, A

J Neurochem 2000
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created