Caspase-mediated cleavage of alpha adducin

Stable Identifier
R-HSA-201608
Type
Reaction [transition]
Species
Homo sapiens
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The cortical actin cytoskeletal network is lost during apoptosis. During apoptosis, increased phosphorylation of the actin capping protein alpha-adducin leads to its dissociation from the cytoskeleton. The caspase-3-mediated cleavage cleavage of alpha adducin at Asp-Asp-Ser-Asp(633)-Ala prevents its reassociation (van de Water et al, 2000).

Literature References
PubMed ID Title Journal Year
10823823 Cleavage of the actin-capping protein alpha -adducin at Asp-Asp-Ser-Asp633-Ala by caspase-3 is preceded by its phosphorylation on serine 726 in cisplatin-induced apoptosis of renal epithelial cells

van de Water, B, Tijdens, IB, Verbrugge, A, Huigsloot, M, Dihal, AA, Stevens, JL, Jaken, S, Mulder, GJ

J Biol Chem 2000
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Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
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Orthologous Events
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