The cortical actin cytoskeletal network is lost during apoptosis. During apoptosis, increased phosphorylation of the actin capping protein alpha-adducin leads to its dissociation from the cytoskeleton. The caspase-3-mediated cleavage cleavage of alpha adducin at Asp-Asp-Ser-Asp(633)-Ala prevents its reassociation (van de Water et al, 2000).
