The cortical actin cytoskeletal network is lost during apoptosis. During apoptosis, increased phosphorylation of the actin capping protein alpha-adducin leads to its dissociation from the cytoskeleton. The caspase-3-mediated cleavage cleavage of alpha adducin at Asp-Asp-Ser-Asp(633)-Ala prevents its reassociation (van de Water et al, 2000).
Verbrugge, A, Jaken, S, Tijdens, IB, Dihal, AA, Huigsloot, M, Stevens, JL, Mulder, GJ, van de Water, B
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
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