pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis

Stable Identifier
R-HSA-200423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
Synonyms
ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Acetyl-CoA carboxylase 2 (ACACB, ACC2) is involved in the regulation of mitochondrial fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA. Phosphorylated AMPK inactivates ACACB in muscle cells by phosphorylation. This results in decreased levels of malonyl CoA, contributing to the homeostasis of mitochondrial beta oxidation (Ruderman & Prentki 2004).
Literature References
PubMed ID Title Journal Year
15060529 AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

Prentki, M, Ruderman, N

Nat Rev Drug Discov 2004
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
fatty acid homeostasis (0055089)
Catalyst Activity

AMP-activated protein kinase activity of AMPK heterotrimer (active) [cytosol]

Physical Entity
AMPK heterotrimer (active) [cytosol] (Homo sapiens)
Activity
AMP-activated protein kinase activity (GO:0004679)
Orthologous Events
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Bos taurus)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Caenorhabditis elegans)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Dictyostelium discoideum)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Drosophila melanogaster)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Mus musculus)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Rattus norvegicus)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Saccharomyces cerevisiae)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Schizosaccharomyces pombe)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Sus scrofa)
Cross References
RHEA
Authored
Gopinathrao, G  (2007-07-30)
Reviewed
D'Eustachio, P  (2007-07-31)
Hill, DP  (2024-08-02)
Created
Gopinathrao, G  (2007-07-18)
Cite Us!