pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis

Stable Identifier
R-HSA-200423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, mitochondrial outer membrane
Synonyms
ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)
ReviewStatus
5/5
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pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis
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Acetyl-CoA carboxylase 2 (ACACB, ACC2) is involved in the regulation of mitochondrial fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA. Phosphorylated AMPK inactivates ACACB in muscle cells by phosphorylation. This results in decreased levels of malonyl CoA, contributing to the homeostasis of mitochondrial beta oxidation (Ruderman & Prentki 2004).
Literature References
PubMed ID Title Journal Year
15060529 AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

Ruderman, N, Prentki, M

Nat Rev Drug Discov 2004
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
fatty acid homeostasis (0055089)
Catalyst Activity

AMP-activated protein kinase activity of AMPK heterotrimer (active) [cytosol]

Physical Entity
AMPK heterotrimer (active) [cytosol] (Homo sapiens)
Activity
AMP-activated protein kinase activity (GO:0004679)
Orthologous Events
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Bos taurus)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Canis familiaris)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Dictyostelium discoideum)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Mus musculus)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Rattus norvegicus)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Saccharomyces cerevisiae)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Schizosaccharomyces pombe)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Sus scrofa)
Cross References
RHEA
Authored
Gopinathrao, G  (2007-07-30)
Reviewed
D'Eustachio, P  (2007-07-31)
Hill, DP  (2024-08-02)
Created
Gopinathrao, G  (2007-07-18)
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