Reactome | p-T154,S315-NCF4 [phagolysosome]

p-T154,S315-NCF4 [phagolysosome]

Stable Identifier

R-HSA-1996221

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

phagolysosome

Synonyms

p-T154,S315-p40phox, Neutrophil cytosol factor 4, NCF4_HUMAN

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
9804763	p40(phox) is phosphorylated on threonine 154 and serine 315 during activation of the phagocyte NADPH oxidase. Implication of a protein kinase c-type kinase in the phosphorylation process Bouin, AP, Grandvaux, N, Vignais, PV, Fuchs, A	J. Biol. Chem.	1998

External Reference Information

External Reference

UniProt:Q15080 NCF4

Gene Names

NCF4, SH3PXD4

Chain

chain:1-339

Reference Genes

BioGPS Gene:4689 NCF4

COSMIC - genes:NCF4 NCF4

CTD Gene:4689 NCF4

dbSNP Gene:4689 NCF4

ENSEMBL:ENSG00000100365 NCF4

HGNC:7662 NCF4

KEGG:hsa:4689 NCF4

Monarch:4689 NCF4

NCBI Gene:4689 NCF4

OMIM:601488 NCF4

UCSC:Q15080 NCF4

Reference Transcript

Other Identifiers

11723106_a_at

16929662

205147_PM_x_at

205147_x_at

207677_PM_s_at

207677_s_at

38893_at

38894_g_at

38895_i_at

3944544

3944545

3944547

3944548

3944549

3944551

3944552

3944553

3944554

3944555

3944556

3944557

3944558

3944559

3944560

3944561

4689

8072744

A_14_P110052

A_23_P109508

A_33_P3365432

GE62052

GO:0005515

GO:0005737

GO:0005764

GO:0005768

GO:0005829

GO:0005886

GO:0006909

GO:0008289

GO:0010008

GO:0016020

GO:0016176

GO:0016192

GO:0031410

GO:0032010

GO:0032266

GO:0035091

GO:0042554

GO:0043020

GO:0045730

HMNXSV003054798

ILMN_1757361

ILMN_1785005

ILMN_2335704

PH_hs_0027302

TC22000270.hg

X77094_at

g7382492_3p_a_at

Participates

as a component of

NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)

Other forms of this molecule

NCF4 [cytosol]

Inferred To

phospho-Ncf4 [phagolysosome] (Rattus norvegicus)

phospho-ncf4 [phagolysosome] (Danio rerio)

phospho-ncf4 [phagolysosome] (Xenopus tropicalis)

phospho-NCF4 [phagolysosome] (Canis familiaris)

phospho-NCF4 [phagolysosome] (Gallus gallus)

phospho-NCF4 [phagolysosome] (Sus scrofa)

phospho-p-T154,S315-NCF4 [phagolysosome] (Bos taurus)

phospho-p-T154,S315-NCF4 [phagolysosome] (Mus musculus)

Modified Residues

Name

O-phospho-L-threonine at 154

Coordinate

154

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 315

Coordinate

315

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_000622.2, NP_038202.2

ENSEMBL

ENSP00000380334, ENST00000397147, ENSP00000248899, ENST00000248899, ENSG00000100365

OpenTargets

ENSG00000100365

GeneCards

NCF4

HPA

ENSG00000100365-NCF4

PRO

Q15080

Pharos - Targets

Q15080

GlyGen

Q15080

Orphanet

NCF4

HMDB Protein

HMDBP01615

PDB

1W70, 1H6H, 1W6X, 2DYB, 1Z9Q, 1OEY