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NCF4 [cytosol]
Stable Identifier
R-HSA-1222707
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p40phox
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
NOX2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
MAPK1 or MAPK3 phosphorylates NCF1 at Ser345 (Homo sapiens)
NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
MAPK11 or MAPK14 phosphorylates NCF1 at Ser345 (Homo sapiens)
NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
NADPH oxidase 2 (NOX2) complex binds RAC1 (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
NADPH oxidase 2 generates superoxide from oxygen (Homo sapiens)
NOX2 complex:RAC1:GTP [plasma membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
PIN1 binds p-S345-NCF1 (Homo sapiens)
PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
PKC phosphorylates NCF1 (Homo sapiens)
PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
PIN1:p-S-6S-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
RAC3 GTPase cycle (Homo sapiens)
RAC3 binds effectors at the plasma membrane (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
RAC3:GTP:RAC3 effectors [plasma membrane] (Homo sapiens)
RAC3 effectors [cytosol] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15080 NCF4
Gene Names
NCF4, SH3PXD4
Chain
chain:1-339
Reference Genes
BioGPS Gene:4689 NCF4
COSMIC (genes):NCF4 NCF4
CTD Gene:4689 NCF4
dbSNP Gene:4689 NCF4
ENSEMBL:ENSG00000100365 NCF4
HGNC:7662 NCF4
KEGG:hsa:4689 NCF4
Monarch:4689 NCF4
NCBI Gene:4689 NCF4
OMIM:601488 NCF4
UCSC:Q15080 NCF4
Reference Transcript
RefSeq:NM_000631.4 NCF4
RefSeq:NM_013416.3 NCF4
Other Identifiers
11723106_a_at
16929662
205147_PM_x_at
205147_x_at
207677_PM_s_at
207677_s_at
38893_at
38894_g_at
38895_i_at
3944544
3944545
3944547
3944548
3944549
3944551
3944552
3944553
3944554
3944555
3944556
3944557
3944558
3944559
3944560
3944561
4689
8072744
A_14_P110052
A_23_P109508
A_33_P3365432
GE62052
GO:0005515
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0006909
GO:0008289
GO:0010008
GO:0016020
GO:0016176
GO:0016192
GO:0031410
GO:0032010
GO:0032266
GO:0035091
GO:0042554
GO:0043020
GO:0043226
GO:0045730
GO:0098772
HMNXSV003054798
ILMN_1757361
ILMN_1785005
ILMN_2335704
PH_hs_0027302
TC22000270.hg
X77094_at
g7382492_3p_a_at
Participates
as a component of
NOX2 complex [phagocytic vesicle membrane] (Homo sapiens)
NOX2 complex [plasma membrane] (Homo sapiens)
NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
PIN1:p-S-6S-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
PIN1:p-S-345-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
Other forms of this molecule
p-T154,S315-NCF4 [phagolysosome]
Inferred To
Ghost homologue of NCF4 [cytosol]
(Danio rerio)
Ncf4 [cytosol]
(Rattus norvegicus)
ncf4 [cytosol]
(Xenopus tropicalis)
NCF4 [cytosol]
(Bos taurus)
NCF4 [cytosol]
(Canis familiaris)
NCF4 [cytosol]
(Gallus gallus)
NCF4 [cytosol]
(Mus musculus)
NCF4 [cytosol]
(Sus scrofa)
BEM1 [cytosol]
(Saccharomyces cerevisiae)
scd2 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_038202.2
,
NP_000622.2
ENSEMBL
ENST00000248899
,
ENST00000397147
,
ENSP00000248899
,
ENSP00000380334
OpenTargets
ENSG00000100365
HPA
ENSG00000100365-NCF4
PRO
Q15080
Pharos - Targets
Q15080
GlyGen
Q15080
Orphanet
NCF4
HMDB Protein
HMDBP01615
PDB
1H6H
,
1W6X
,
2DYB
,
1W70
,
1OEY
,
1Z9Q
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