GSTO dimers reduce DeHA to AscH-

Stable Identifier
R-HSA-198813
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
dehydroascorbate (DHA) + 2 glutathione (GSH) => ascorbate + oxidized glutathione (GSSG)
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Cytosolic omega class glutathione transferases (GSTO1 and GSTO2) catalyze the reaction of dehydroascorbate (DeHA) and glutathione (GSH) to form ascorbate (AscH-) and oxidized glutathione (GSSG). The GSTO enzymes occur as homodimers (Board et al. 2000), and while both have dehydroascorbate reductase activity in vitro, that of GSTO2 is much greater than that of GSTO1 (Schmuck et al. 2005). Polymorphisms affecting the activities of the two enzymes have been described (Whitbread et al. 2005).

Literature References
PubMed ID Title Journal Year
10783391 Identification, characterization, and crystal structure of the Omega class glutathione transferases

Board, PG, Coggan, M, Chelvanayagam, G, Easteal, S, Jermiin, LS, Schulte, GK, Danley, DE, Hoth, LR, Griffor, MC, Kamath, AV, Rosner, MH, Chrunyk, BA, Perregaux, DE, Gabel, CA, Geoghegan, KF, Pandit, J

J Biol Chem 2000
15970797 Characterization of the monomethylarsonate reductase and dehydroascorbate reductase activities of Omega class glutathione transferase variants: implications for arsenic metabolism and the age-at-onset of Alzheimer's and Parkinson's diseases

Schmuck, EM, Board, PG, Whitbread, AK, Tetlow, N, Cavanaugh, JA, Blackburn, AC, Masoumi, A

Pharmacogenet Genomics 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glutathione dehydrogenase (ascorbate) activity of GSTO dimers [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created
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