Reactome | NOTCH1 stimulates HEY transcription

NOTCH1 stimulates HEY transcription

Stable Identifier

R-HSA-1980065

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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RBPJ binding sites in the promoters of HEY1, HEY2 and HEYL genes are conserved between humans and mice (Maier and Gessler 2000), and expression of human NICD1 was directly shown to activate transcription from human HEY2 and HEYL promoters (Arnett et al. 2010). Based on the evolutionary conservation of RBPJ sites and the existing findings from human and mouse studies, NOTCH1 is expected to directly stimulate transcription of HEY1, HEY2 and HEYL (Fischer et al. 2004, Leimeister et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
11044625	Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos Leimeister, C, Schumacher, N, Steidl, C, Gessler, M	Mech Dev	2000
20972443	Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes Arnett, KL, Hass, M, McArthur, DG, Ilagan, MXG, Aster, JC, Kopan, R, Blacklow, SC	Nat Struct Mol Biol	2010
10964718	Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes Maier, MM, Gessler, M	Biochem Biophys Res Commun	2000
15107403	The Notch target genes Hey1 and Hey2 are required for embryonic vascular development Fischer, A, Schumacher, N, Maier, M, Sendtner, M, Gessler, M	Genes Dev	2004