NOTCH1 stimulates HEY transcription

Stable Identifier
Reaction [omitted]
Homo sapiens
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RBPJ binding sites in the promoters of HEY1, HEY2 and HEYL genes are conserved between humans and mice (Maier and Gessler 2000), and expression of human NICD1 was directly shown to activate transcription from human HEY2 and HEYL promoters (Arnett et al. 2010). Based on the evolutionary conservation of RBPJ sites and the existing findings from human and mouse studies, NOTCH1 is expected to directly stimulate transcription of HEY1, HEY2 and HEYL (Fischer et al. 2004, Leimeister et al. 2000).

Literature References
PubMed ID Title Journal Year
11044625 Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

Gessler, M, Schumacher, N, Steidl, C, Leimeister, C

Mech Dev 2000
20972443 Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

McArthur, DG, Kopan, R, Blacklow, SC, Arnett, KL, Hass, M, Aster, JC, Ilagan, MXG

Nat Struct Mol Biol 2010
10964718 Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

Gessler, M, Maier, MM

Biochem Biophys Res Commun 2000
15107403 The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

Gessler, M, Schumacher, N, Maier, M, Sendtner, M, Fischer, A

Genes Dev 2004
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