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UNC5A [plasma membrane]
Stable Identifier
R-HSA-197679
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Netrin receptor UNC5A, UN5A_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
Netrin mediated repulsion signals (Homo sapiens)
DCC heterodimerizes with UNC-5:Netrin-1 (Homo sapiens)
DCC:NTN1:UNC5 [plasma membrane] (Homo sapiens)
NTN1:UNC5 [plasma membrane] (Homo sapiens)
UNC5 [plasma membrane] (Homo sapiens)
UNC5A [plasma membrane] (Homo sapiens)
NTN1:UNC5 [plasma membrane] (Homo sapiens)
UNC5 [plasma membrane] (Homo sapiens)
UNC5A [plasma membrane] (Homo sapiens)
UNC-5 binds Netrin-1 (Homo sapiens)
NTN1:UNC5 [plasma membrane] (Homo sapiens)
UNC5 [plasma membrane] (Homo sapiens)
UNC5A [plasma membrane] (Homo sapiens)
UNC5 [plasma membrane] (Homo sapiens)
UNC5A [plasma membrane] (Homo sapiens)
Netrin-4 binds DCC/UNC5A (Homo sapiens)
DCC, UNC5A [plasma membrane] (Homo sapiens)
UNC5A [plasma membrane] (Homo sapiens)
NTN4:DCC,UNC5A [plasma membrane] (Homo sapiens)
DCC, UNC5A [plasma membrane] (Homo sapiens)
UNC5A [plasma membrane] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
Caspase cleavage of UNC5A (Homo sapiens)
UNC5A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6ZN44 UNC5A
Gene Names
UNC5A, KIAA1976, UNC5H1
Chain
signal peptide:1-25, chain:26-842
Reference Genes
BioGPS Gene:90249 UNC5A
COSMIC (genes):UNC5A UNC5A
CTD Gene:90249 UNC5A
dbSNP Gene:90249 UNC5A
ENSEMBL:ENSG00000113763 UNC5A
HGNC:12567 UNC5A
KEGG:hsa:90249 UNC5A
Monarch:90249 UNC5A
NCBI Gene:90249 UNC5A
OMIM:607869 UNC5A
UCSC:Q6ZN44 UNC5A
Reference Transcript
RefSeq:NM_133369.2 UNC5A
Other Identifiers
11730490_at
16992918
236448_PM_at
236448_at
2842787
2842789
2842791
2842793
2842795
2842797
2842799
2842801
2842803
2842805
2842807
2842819
2842821
2842823
2842825
2842827
2842829
2842835
2842837
2842839
2842841
2842843
2842845
2842847
47437_at
8110237
88651_at
90249
A_23_P110557
A_33_P3379001
GO:0005042
GO:0005515
GO:0005886
GO:0006915
GO:0007165
GO:0012501
GO:0016020
GO:0031175
GO:0032589
GO:0032809
GO:0033564
GO:0038007
GO:0042995
GO:0043005
GO:0045121
GO:0060089
HMNXSV003043676
Hs.119486.0.A1_3p_at
ILMN_1712913
PH_hs_0002789
TC05001007.hg
Participates
as a member of
DCC, UNC5A [plasma membrane] (Homo sapiens)
UNC5 [plasma membrane] (Homo sapiens)
as an input of
Caspase cleavage of UNC5A (Homo sapiens)
Other forms of this molecule
UNC5A(26-340) [plasma membrane]
UNC5A(341-842) [cytosol]
Inferred To
Unc5a [plasma membrane]
(Mus musculus)
Unc5a [plasma membrane]
(Rattus norvegicus)
unc-5 [plasma membrane]
(Caenorhabditis elegans)
unc-5 [plasma membrane]
(Drosophila melanogaster)
unc5a [plasma membrane]
(Xenopus tropicalis)
UNC5A [plasma membrane]
(Bos taurus)
UNC5A [plasma membrane]
(Canis familiaris)
UNC5A [plasma membrane]
(Gallus gallus)
UNC5A [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_588610.2
ENSEMBL
ENST00000329542
,
ENSP00000332737
OpenTargets
ENSG00000113763
HPA
ENSG00000113763-UNC5A
PRO
Q6ZN44
Pharos - Targets
Q6ZN44
GlyGen
Q6ZN44
PDB
4V2A
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