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Caspase cleavage of UNC5A
Stable Identifier
R-HSA-418846
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
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Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
Caspase cleavage of UNC5A (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The UNC5H netrin1 receptors also contain death domains in their intracellular regions and function as dependence receptors. The cleavage site sequence DITD(S) found in UNC5H2 appears to be a classic caspase DXXD site and is conserved in UNC5H1 and UNC5H3 (DVAD(S) and DIID(S), respectively).
Participants
Input
UNC5A [plasma membrane]
(Homo sapiens)
Output
UNC5A(26-340) [plasma membrane]
(Homo sapiens)
UNC5A(341-842) [cytosol]
(Homo sapiens)
Participates
as an event of
Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
Catalyst Activity
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Caspase-3 [cytosol]
(Homo sapiens)
Activity
cysteine-type endopeptidase activity (GO:0004197)
Inferred From
Caspase cleavage of Unc5h1 (Mus musculus)
Authored
Garapati, P V (2008-07-16)
Reviewed
Cooper, HM (2010-02-16)
Created
Garapati, P V (2009-04-27)
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