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HLA class II histocompatibility antigen, DQ [plasma membrane]
Stable Identifier
R-HSA-197578
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
HB21_HUMAN, HLA-DQB
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
MHC class II antigen presentation (Homo sapiens)
Insertion of MHC II:Ii complex in to the plasma membrane (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Internalization of MHC II:Ii clathrin coated vesicle (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
LAG3 (CD233) binds MHC II (Homo sapiens)
LAG3:MHC II [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Recruitment of clathrin coated vesicle by Ii (Homo sapiens)
Clathrin coated MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
MHC class II alpha/beta/Ii nonamer [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Transport of antigen loaded MHC II molecules to surface (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Regulation of T cell activation by CD28 family (Homo sapiens)
Co-inhibition by PD-1 (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
Antigen-bearing MHC Class II: TCR with dephosphorylated CD3 zeta chain:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
TCR signaling (Homo sapiens)
Downstream TCR signaling (Homo sapiens)
Change of PKC theta conformation (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Phosphorylation of PLC-gamma1 (Homo sapiens)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Phosphorylation of SLP-76 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Phosphorylation of TBSMs in LAT (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Phosphorylation of CD3 and TCR zeta chains (Homo sapiens)
Activation of Lck (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Dephosphorylation of Lck-pY505 by CD45 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Inactivation of LCK by PTPN22 (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Inactivation of Lck by Csk (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II : TCR complex:CD4:p-Lck(Y505) [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Phosphorylation of ITAM motifs in CD3 complexes (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Translocation of ZAP-70 to Immunological synapse (Homo sapiens)
Activation of ZAP-70 (Homo sapiens)
Activated ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
PTPN22 dephosphorylates ZAP70 (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Phosphorylation of ZAP-70 by Lck (Homo sapiens)
Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Recruitment of ZAP-70 to phosphorylated ITAMs (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] (Homo sapiens)
Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] (Homo sapiens)
MHC Class II bearing antigen peptide [plasma membrane] (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Expression of IFNG-stimulated genes (Homo sapiens)
MHC class II alpha/beta dimer [plasma membrane] (Homo sapiens)
HLA II beta chain [plasma membrane] (Homo sapiens)
HLA class II histocompatibility antigen, DQ [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01920 HLA-DQB1
Gene Names
HLA-DQB1, HLA-DQB
Chain
signal peptide:1-32, chain:33-261
Reference Genes
BioGPS Gene:3119 HLA-DQB1
COSMIC (genes):HLA-DQB1 HLA-DQB1
CTD Gene:3119 HLA-DQB1
dbSNP Gene:3119 HLA-DQB1
HGNC:4944 HLA-DQB1
KEGG:hsa:3119 HLA-DQB1
Monarch:3119 HLA-DQB1
NCBI Gene:3119 HLA-DQB1
OMIM:604305 HLA-DQB1
UCSC:P01920 HLA-DQB1
Reference Transcript
RefSeq:NM_001243962.1 HLA-DQB1
RefSeq:NM_002123.4 HLA-DQB1
Other Identifiers
11762317_a_at
11762935_x_at
17029721
17032405
17034731
17037200
17039923
209823_PM_x_at
209823_x_at
211656_3p_x_at
211656_PM_x_at
211656_x_at
212998_PM_x_at
212998_x_at
2950077
2950078
2950079
2950081
2950086
2950087
2950088
2950089
2950090
2950091
2950092
2950093
2950094
2950095
2950096
2950097
2950098
2950104
2950131
2950138
3119
36773_f_at
36878_f_at
47867_at
8178826
8180022
88368_at
A_21_P0013995
A_23_P8108
A_33_P3424217
GE85243
GO:0000139
GO:0002250
GO:0002376
GO:0002503
GO:0002504
GO:0005515
GO:0005764
GO:0005765
GO:0005768
GO:0005773
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0006955
GO:0006959
GO:0010008
GO:0012507
GO:0016020
GO:0019882
GO:0019886
GO:0023026
GO:0030658
GO:0030666
GO:0030669
GO:0031410
GO:0031902
GO:0032395
GO:0032588
GO:0042605
GO:0042613
GO:0043226
GO:0050778
GO:0050852
GO:0050870
GO:0060089
GO:0065003
GO:0098553
HMNXSV003024515
HMNXSV003051645
Hs.73931.3.A1_3p_x_at
ILMN_1661266
K02405_f_at
TC6_cox_hap2000195.hg
TC6_dbb_hap3000181.hg
TC6_mann_hap4000163.hg
TC6_mcf_hap5000170.hg
TC6_qbl_hap6000183.hg
TC6_ssto_hap7000165.hg
g188178_3p_x_at
g188194_3p_s_at
Participates
as a member of
HLA II beta chain [plasma membrane] (Homo sapiens)
Other forms of this molecule
HLA class II histocompatibility antigen, DQ [lysosomal membrane]
HLA class II histocompatibility antigen, DQ [endocytic vesicle membrane]
HLA class II histocompatibility antigen, DQ [clathrin-coated endocytic vesicle membrane]
HLA class II histocompatibility antigen, DQ [transport vesicle membrane]
HLA class II histocompatibility antigen, DQ [trans-Golgi network membrane]
HLA class II histocompatibility antigen, DQB1*0602 beta chain precursor [Golgi membrane]
HLA class II histocompatibility antigen, DQ [ER to Golgi transport vesicle membrane]
HLA class II histocompatibility antigen, DQ [lumenal side of endoplasmic reticulum membrane]
Inferred To
BOLA-DQB [plasma membrane]
(Bos taurus)
b2m [plasma membrane]
(Danio rerio)
BLB2 [plasma membrane]
(Gallus gallus)
zmp:0000001138 [plasma membrane]
(Danio rerio)
RT1-Bb [plasma membrane]
(Rattus norvegicus)
BLB1 [plasma membrane]
(Gallus gallus)
HLA class II histocompatibility antigen, DQ [plasma membrane]
(Canis familiaris)
HLA class II histocompatibility antigen, DQ [plasma membrane]
(Gallus gallus)
HLA class II histocompatibility antigen, DQ [plasma membrane]
(Sus scrofa)
mhc2-dab [plasma membrane]
(Xenopus tropicalis)
H2-Ab1 [plasma membrane]
(Mus musculus)
Homologues of HLA class II histocompatibility antigen, DQ [plasma membrane]
(Danio rerio)
Homologues of HLA class II histocompatibility antigen, DQ [plasma membrane]
(Gallus gallus)
Homologues of HLA class II histocompatibility antigen, DQ [plasma membrane]
(Sus scrofa)
Cross References
RefSeq
NP_001230891.1
,
NP_002114.3
OpenTargets
ENSG00000179344
ENSEMBL
ENSG00000231286
,
ENSP00000382038
,
ENSP00000410107
,
ENST00000416192
,
ENST00000422950
,
ENSP00000410330
,
ENSP00000414079
,
ENSG00000225824
,
ENSP00000402865
,
ENSP00000396539
,
ENST00000413089
,
ENST00000424806
,
ENST00000399088
,
ENST00000419914
,
ENSG00000233209
GeneCards
HLA-DQB1
PRO
P01920
Pharos - Targets
P01920
Orphanet
HLA-DQB1
GlyGen
P01920
PDB
1UVQ
,
4OZI
,
2NNA
,
4OZF
,
4OZH
,
1S9V
,
4GG6
,
8VSP
,
4OZG
,
1JK8
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