ADP-Ribosylation of HNP-1

Stable Identifier
R-HSA-1972385
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ADP-Ribosylation of HNP-1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

HNP-1 is recognized as a substrate by arginine-specific ADP-ribosyltransferase-1 which ribosylates Arg-14 of the peptide. The modified defensin has reduced antimicrobial and cytotoxic activities but its chemotactic properties remain unchanged whilst its ability to induced the chemokine IL-8 is enhanced.

Literature References
PubMed ID Title Journal Year
12060767 ADP ribosylation of human neutrophil peptide-1 regulates its biological properties

Paone, G, Wada, A, Stevens, LA, Matin, A, Hirayama, T, Levine, RL, Moss, J

Proc Natl Acad Sci U S A 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NAD(P)+-protein-arginine ADP-ribosyltransferase activity of ART1 [plasma membrane]
Physical Entity
ART1 [plasma membrane]
Activity
NAD(P)+-protein-arginine ADP-ribosyltransferase activity (0003956)
Orthologous Events
ADP-Ribosylation of HNP-1 (Mus musculus)
ADP-Ribosylation of HNP-1 (Rattus norvegicus)
Authored
Jupe, S  (2011-11-04)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-11-04)