ADP-Ribosylation of HNP-1

Stable Identifier
R-HSA-1972385
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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ADP-Ribosylation of HNP-1
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HNP-1 is recognized as a substrate by arginine-specific ADP-ribosyltransferase-1 which ribosylates Arg-14 of the peptide. The modified defensin has reduced antimicrobial and cytotoxic activities but its chemotactic properties remain unchanged whilst its ability to induced the chemokine IL-8 is enhanced.

Literature References
PubMed ID Title Journal Year
12060767 ADP ribosylation of human neutrophil peptide-1 regulates its biological properties

Paone, G, Wada, A, Stevens, LA, Matin, A, Hirayama, T, Levine, RL, Moss, J

Proc Natl Acad Sci U S A 2002
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
NAD(P)+-protein-arginine ADP-ribosyltransferase activity of ART1 [plasma membrane]
Physical Entity
ART1 [plasma membrane]
Activity
NAD(P)+-protein-arginine ADP-ribosyltransferase activity (0003956)
Orthologous Events
ADP-Ribosylation of HNP-1 (Mus musculus)
ADP-Ribosylation of HNP-1 (Rattus norvegicus)
Authored
Jupe, S  (2011-11-04)
Reviewed
McDermott, AM  (2011-11-03)
Created
Jupe, S  (2011-11-04)
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