Reactome | RFK:Mg2+ phosphorylates RIB

RFK:Mg2+ phosphorylates RIB

Stable Identifier

R-HSA-196964

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ATP + riboflavin => ADP + FMN + H(+)

ReviewStatus

5/5

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Phosphorylation of riboflavin (RIB) results in the formation of the first cofactor, flavin mononucleotide (FMN). This reaction is catalyzed by riboflavin kinase (RFK), a cytosolic enzyme existing as a monomer. It utilizes either zinc or magnesium ions in the reaction.

Literature References

PubMed ID	Title	Journal	Year
12623014	Crystal structure of human riboflavin kinase reveals a beta barrel fold and a novel active site arch Karthikeyan, S, Zhou, Q, Mseeh, F, Grishin, NV, Osterman, AL, Zhang, H	Structure	2003