Reactome | Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol

Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol

Stable Identifier

R-HSA-196402

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

7-dehydrodesmosterol + NADPH + H(+) => desmosterol + NADP(+)

ReviewStatus

5/5

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Cholesta-5,7,24-trien-3beta-ol is reduced to desmosterol

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Cholesta-5,7,24-trien-3beta-ol and NADPH + H+ react to form desmosterol and NADP+. This reaction is catalyzed by DHCR7, associated with the endoplasmic reticulum membrane. The biochemical details of the reaction are inferred from those of the reaction catalyzed by the well-studied rat enzyme (Bae et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9465114	Molecular cloning and expression of the human delta7-sterol reductase Moebius, FF, Fitzky, BU, Lee, JN, Paik, YK, Glossmann, H	Proc Natl Acad Sci U S A	1998