CYP19A1 hydroxylates TEST to EST17b

Stable Identifier
R-HSA-193143
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Testosterone is converted to estradiol
Locations in the PathwayBrowser
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The conversion of testosterone to estradiol is catalyzed by aromatase (CYP19A1) associated with the endoplasmic reticulum membrane.

Literature References
PubMed ID Title Journal Year
2171939 Structural and functional characterization of human aromatase P-450 gene

Toda, K, Terashima, M, Kawamoto, T, Sumimoto, H, Yokoyama, Y, Kuribayashi, I, Mitsuuchi, Y, Maeda, T, Yamamoto, Y, Sagara, Y

Eur J Biochem 1990
8076586 Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis

Simpson, ER, Mahendroo, MS, Means, GD, Kilgore, MW, Hinshelwood, MM, Graham-Lorence, S, Amarneh, B, Ito, Y, Fisher, CR, Michael, MD, Mendelson, CR, Bulun, SE

Endocr Rev 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid hydroxylase activity of CYP19A1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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