vRNA Extension

Stable Identifier
R-HSA-192851
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
nucleoplasm
ReviewStatus
5/5
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vRNA Extension
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vRNA is synthesized from the complementary cRNA strand by the trimeric polymerase complex, and bound by free NP protein (Honda, 1988; Mikulasova, 2000; Neumann, 2004). The PB1 subunit, with PA, catalyzes extension (Nakagawa, 1996). The cRNA is released.
Literature References
PubMed ID Title Journal Year
15298169 Orthomyxovirus replication, transcription, and polyadenylation

Neumann, G, Brownlee, GG, Fodor, E, Kawaoka, Y

Curr Top Microbiol Immunol 2004
11252672 Transcription and replication of the influenza a virus genome

Mikulasova, A, Vareckova, E, Fodor, E

Acta Virol 2000
8709268 The PB1 subunit alone can catalyze cRNA synthesis, and the PA subunit in addition to the PB1 subunit is required for viral RNA synthesis in replication of the influenza virus genome

Nakagawa, Y, Oda, K, Nakada, S

J Virol 1996
3243763 RNA polymerase of influenza virus: role of NP in RNA chain elongation

Honda, A, Ueda, K, Nagata, K, Ishihama, A

J Biochem (Tokyo) 1988
Participants
Input
Output
Participates
as an event of
Catalyst Activity

RNA-directed RNA polymerase activity of Viral Polymerase [nucleoplasm]

Physical Entity
Viral Polymerase [nucleoplasm] (Influenza A virus)
Activity
RNA-directed RNA polymerase activity (GO:0003968)
Disease
Name Identifier Synonyms
influenza DOID:8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Cross References
Mondo
Authored
Bortz, E  (2007-02-13)
Garcia-Sastre, A  (2007-02-13)
Reviewed
Squires, B  (2007-02-13)
Created
Gillespie, ME  (2007-02-07)
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