vRNA Extension

Stable Identifier
R-HSA-192851
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Locations in the PathwayBrowser
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vRNA is synthesized from the complementary cRNA strand by the trimeric polymerase complex, and bound by free NP protein (Honda, 1988; Mikulasova, 2000; Neumann, 2004). The PB1 subunit, with PA, catalyzes extension (Nakagawa, 1996). The cRNA is released.

Literature References
PubMed ID Title Journal Year
11252672 Transcription and replication of the influenza a virus genome

Mikulasova, A, Vareckova, E, Fodor, E

Acta Virol 2000
15298169 Orthomyxovirus replication, transcription, and polyadenylation

Neumann, G, Brownlee, GG, Fodor, E, Kawaoka, Y

Curr Top Microbiol Immunol 2004
8709268 The PB1 subunit alone can catalyze cRNA synthesis, and the PA subunit in addition to the PB1 subunit is required for viral RNA synthesis in replication of the influenza virus genome

Nakagawa, Y, Oda, K, Nakada, S

J Virol 1996
3243763 RNA polymerase of influenza virus: role of NP in RNA chain elongation

Honda, A, Ueda, K, Nagata, K, Ishihama, A

J Biochem (Tokyo) 1988
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
RNA-directed 5'-3' RNA polymerase activity of Viral Polymerase [nucleoplasm]
Physical Entity
Activity
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Reviewed
Created
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