The synthesis of full-length negative strand viral RNA from a cRNA template is believed to follow the same principles as the synthesis of cRNA from a vRNA template. The cRNA, complexed with viral nucleocapsid (NP) protein, is used as template by the trimeric viral polymerase (Pritlove, 1995; Vreede, 2004; Crow, 2004), and newly synthesized vRNA molecules are immediately packaged with NP molecules to form ribonucleoprotein complexes (Vreede, 2004). There is some evidence that the production of vRNA-containing vRNP occurs in the nuclear matrix as well as the nucleoplasm (Takizawa, 2006).
Jung, TE, Brownlee, GG, Vreede, FT
Seong, BL, Fodor, E, Pritlove, DC, Brownlee, GG
Crow, M, Brownlee, GG, Deng, T, Addley, M
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