Initiation of cRNA Synthesis

Stable Identifier
R-HSA-192832
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
Locations in the PathwayBrowser
General
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Viral vRNA, complexed with NP protein, is bound by the trimeric viral polymerase complex in a stable secondary structure-dependent manner, referred to as a panhandle, fork or cork-screw (Fodor, 1994; Brownlee, 2002; Park, 2003; Crow, 2004). This RNA structure is made of both the 5’ and 3' ends of the vRNA. The polymerase is thought to first bind the 5' end of the vRNA and then the 3' end. Synthesis of cRNA initiates without a host cell methylated RNA cap as a primer (Beaton, 1986; Galarza, 1996; Deng, 2006; Engehardt, 2006).

Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
RNA-directed 5'-3' RNA polymerase activity of Viral Polymerase [nucleoplasm]
Physical Entity
Activity
This event is regulated
Positively by
Disease
Name Identifier Synonyms
influenza 8469 Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation
Authored
Reviewed
Created
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