Reactome | Initiation of cRNA Synthesis

Initiation of cRNA Synthesis

Stable Identifier

R-HSA-192832

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Influenza A virus

Compartment

nucleoplasm

ReviewStatus

5/5

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        cRNA Synthesis (Homo sapiens)
        
        Initiation of cRNA Synthesis (Homo sapiens)

General

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Viral vRNA, complexed with NP protein, is bound by the trimeric viral polymerase complex in a stable secondary structure-dependent manner, referred to as a panhandle, fork or cork-screw (Fodor, 1994; Brownlee, 2002; Park, 2003; Crow, 2004). This RNA structure is made of both the 5’ and 3' ends of the vRNA. The polymerase is thought to first bind the 5' end of the vRNA and then the 3' end. Synthesis of cRNA initiates without a host cell methylated RNA cap as a primer (Beaton, 1986; Galarza, 1996; Deng, 2006; Engehardt, 2006).

Literature References

PubMed ID	Title	Journal	Year
16474140	Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication Deng, T, Vreede, FT, Brownlee, GG	J Virol	2006
12072510	The RNA polymerase of influenza a virus is stabilized by interaction with its viral RNA promoter Brownlee, GG, Sharps, JL	J Virol	2002
8189550	The influenza virus panhandle is involved in the initiation of transcription Fodor, E, Pritlove, DC, Brownlee, GG	J Virol	1994
15163719	Mutational analysis of the influenza virus cRNA promoter and identification of nucleotides critical for replication Crow, M, Deng, T, Addley, M, Brownlee, GG	J Virol	2004

Participants

Input

Output

Initiated vRNA-cRNA Complex [nucleoplasm] (Influenza A virus)

Participates

as an event of

cRNA Synthesis (Homo sapiens)

Catalyst Activity

RNA-directed RNA polymerase activity of Viral Polymerase [nucleoplasm]

Physical Entity

Viral Polymerase [nucleoplasm] (Influenza A virus)

Activity

RNA-directed RNA polymerase activity (GO:0003968)

This event is regulated

Positively by

Regulator

NP [nucleoplasm] (Influenza A virus)

Disease

Name	Identifier	Synonyms
influenza	DOID:8469	Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation

Cross References

Mondo

0005812

Authored

Bortz, E (2007-02-13)

Garcia-Sastre, A (2007-02-13)

Reviewed

Squires, B (2007-02-13)

Created

Gillespie, ME (2007-02-07)

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