Initiation of cRNA Synthesis

Stable Identifier
R-HSA-192832
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Influenza A virus
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
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Viral vRNA, complexed with NP protein, is bound by the trimeric viral polymerase complex in a stable secondary structure-dependent manner, referred to as a panhandle, fork or cork-screw (Fodor, 1994; Brownlee, 2002; Park, 2003; Crow, 2004). This RNA structure is made of both the 5’ and 3' ends of the vRNA. The polymerase is thought to first bind the 5' end of the vRNA and then the 3' end. Synthesis of cRNA initiates without a host cell methylated RNA cap as a primer (Beaton, 1986; Galarza, 1996; Deng, 2006; Engehardt, 2006).

Participants
Participates
Catalyst Activity

RNA-directed 5'-3' RNA polymerase activity of Viral Polymerase [nucleoplasm]

This event is regulated
Positively by