Reactome | cRNA Synthesis

cRNA Synthesis

Stable Identifier

R-HSA-192869

Type

Pathway

Species

Homo sapiens

Related Species

Influenza A virus

Compartment

nucleoplasm

ReviewStatus

5/5

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Synthesis of full length complementary viral RNA (cRNA) requires that vRNA transcription initiates without the help of a host cell methyl RNA cap as a primer (Crow, 2004; Vreede, 2004; Deng, 2006), and that it proceeds to the 5' end of the vRNA template without stuttering on the sub-terminal poly-U sequence. Free viral NP protein appears to play a central role in enabling both of these features of cRNA synthesis, although the molecular details of its role remain unclear (Shapiro, 1988; Medcalf, 1999; Mullin, 2004).

Literature References

PubMed ID	Title	Journal	Year
16474140	Different de novo initiation strategies are used by influenza virus RNA polymerase on its cRNA and viral RNA promoters during viral RNA replication Brownlee, GG, Vreede, FT, Deng, T	J Virol	2006
15308750	Model suggesting that replication of influenza virus is regulated by stabilization of replicative intermediates Jung, TE, Brownlee, GG, Vreede, FT	J Virol	2004
15163719	Mutational analysis of the influenza virus cRNA promoter and identification of nucleotides critical for replication Crow, M, Brownlee, GG, Deng, T, Addley, M	J Virol	2004

Participants

Events

Participates

as an event of

Influenza Viral RNA Transcription and Replication (Homo sapiens)

Disease

Name	Identifier	Synonyms
influenza	DOID:8469	Influenza with other manifestations (disorder), Influenza with other manifestations NOS (disorder), flu, Influenza with other manifestations, Influenza with non-respiratory manifestation (disorder), influenza with non-respiratory manifestation

Authored

Garcia-Sastre, A (2007-02-13)

Bortz, E (2007-02-13)

Reviewed

Squires, B (2007-02-13)

Created

Gillespie, ME (2007-02-07)

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