CYP7B1 7-hydroxylates 25OH-CHOL

Stable Identifier
R-HSA-192065
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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25-hydroxycholesterol (25OH-CHOL) is 7alpha-hydroxylated to cholest-5-ene-3beta,7alpha,25-triol (CHOL3b,7a,25TRIOL) by CYP7B1 (cytochrome P450 7B1) (Wu et al. 1999).

Literature References
PubMed ID Title Journal Year
10588945 Structure and functions of human oxysterol 7alpha-hydroxylase cDNAs and gene CYP7B1

Wu, Z, Martin, KO, Javitt, NB, Chiang, JY

J Lipid Res 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
oxysterol 7-alpha-hydroxylase activity of Cytochrome P450 (CYP7B1 based) [endoplasmic reticulum membrane]
Physical Entity
Activity
This event is regulated
Orthologous Events
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