Phosphorylation of Cx43 by c-src

Stable Identifier
R-HSA-191636
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of Cx43 by c-src
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
c-Src phosphorylates Cx43 on Tyr 265.
Literature References
PubMed ID Title Journal Year
12506110 Defective activation of c-Src in cystic fibrosis airway epithelial cells results in loss of tumor necrosis factor-alpha-induced gap junction regulation

Thomas, MA, Huang, S, Dudez, T, Scerri, I, Suter, S, Giepmans, BN, Chanson, M

J Biol Chem 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of Cx43:ZO-1:c-src gap junction [plasma membrane]

Physical Entity
Cx43:ZO-1:c-src gap junction [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of Cx43 by c-src (Bos taurus)
Phosphorylation of Cx43 by c-src (Canis familiaris)
Phosphorylation of Cx43 by c-src (Gallus gallus)
Phosphorylation of Cx43 by c-src (Mus musculus)
Phosphorylation of Cx43 by c-src (Rattus norvegicus)
Phosphorylation of Cx43 by c-src (Sus scrofa)
Authored
Gilleron, J  (2007-01-03)
Segretain, D  (2007-01-03)
Falk, MM  (2007-01-03)
Created
Matthews, L  (2007-01-23)
Cite Us!