Phosphorylation of Cx43 by c-src

Stable Identifier
R-HSA-191636
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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Phosphorylation of Cx43 by c-src
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c-Src phosphorylates Cx43 on Tyr 265.
Literature References
PubMed ID Title Journal Year
12506110 Defective activation of c-Src in cystic fibrosis airway epithelial cells results in loss of tumor necrosis factor-alpha-induced gap junction regulation

Huang, S, Dudez, T, Scerri, I, Thomas, MA, Giepmans, BN, Suter, S, Chanson, M

J Biol Chem 2003
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Output
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as an event of
Catalyst Activity

protein tyrosine kinase activity of Cx43:ZO-1:c-src gap junction [plasma membrane]

Physical Entity
Cx43:ZO-1:c-src gap junction [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Phosphorylation of Cx43 by c-src (Canis familiaris)
Phosphorylation of Cx43 by c-src (Gallus gallus)
Phosphorylation of Cx43 by c-src (Mus musculus)
Phosphorylation of Cx43 by c-src (Rattus norvegicus)
Phosphorylation of Cx43 by c-src (Sus scrofa)
Authored
Gilleron, J  (2007-01-03)
Segretain, D  (2007-01-03)
Falk, MM  (2007-01-03)
Created
Matthews, L  (2007-01-23)
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