Regulation of gap junction activity

Stable Identifier
Homo sapiens
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Src is believed to suppress gap junction communication by phosphorylating Cx43. The kinases c-Src (Giepmans et al. 2001; Sorgen et al. 2004), PKc (Lin et al. 2003) and MAPK (Mograbi et al. 2003) play an essential role in the phosphorylation of Cx which leads to its degradation. c-Src appears to associate with and phosphorylate Cx43 leading to closure of gap junctions. Evidence suggests that v-src may activate MAPK, which in turn phosphorylates Cx43 on serine sites leading to channel gating (Zhou et al. 1999).

Literature References
PubMed ID Title Journal Year
14638725 Protein kinase Cgamma regulation of gap junction activity through caveolin-1-containing lipid rafts

Zhou, J, Zelenka, PS, Takemoto, DJ, Lin, D

Invest Ophthalmol Vis Sci 2003
10085299 Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels

Kasperek, EM, Nicholson, BJ, Zhou, L

J Cell Biol 1999
15492000 Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1

Sahoo, P, Spray, DC, Duffy, HS, Delmar, M, Sorgen, PL, Coombs, W

J Biol Chem 2004
11124251 Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication.

Moolenaar, WH, Giepmans, BN, Hengeveld, T, Postma, FR

J Biol Chem 2001
12807735 Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway

Mograbi, B, Samson, M, Defamie, N, Pointis, G, Corcelle, E, Segretain, D, Fenichel, P, Nebout, M

Carcinogenesis 2003
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