Reactome | Regulation of gap junction activity

Regulation of gap junction activity

Stable Identifier

R-HSA-191650

DOI

10.3180/REACT_11034.1

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Src is believed to suppress gap junction communication by phosphorylating Cx43. The kinases c-Src (Giepmans et al. 2001; Sorgen et al. 2004), PKc (Lin et al. 2003) and MAPK (Mograbi et al. 2003) play an essential role in the phosphorylation of Cx which leads to its degradation. c-Src appears to associate with and phosphorylate Cx43 leading to closure of gap junctions. Evidence suggests that v-src may activate MAPK, which in turn phosphorylates Cx43 on serine sites leading to channel gating (Zhou et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
14638725	Protein kinase Cgamma regulation of gap junction activity through caveolin-1-containing lipid rafts Zhou, J, Zelenka, PS, Takemoto, DJ, Lin, D	Invest Ophthalmol Vis Sci	2003
10085299	Dissection of the molecular basis of pp60(v-src) induced gating of connexin 43 gap junction channels Kasperek, EM, Nicholson, BJ, Zhou, L	J Cell Biol	1999
15492000	Structural changes in the carboxyl terminus of the gap junction protein connexin43 indicates signaling between binding domains for c-Src and zonula occludens-1 Sahoo, P, Spray, DC, Duffy, HS, Delmar, M, Sorgen, PL, Coombs, W	J Biol Chem	2004
11124251	Interaction of c-Src with gap junction protein connexin-43. Role in the regulation of cell-cell communication. Moolenaar, WH, Giepmans, BN, Hengeveld, T, Postma, FR	J Biol Chem	2001
12807735	Aberrant Connexin 43 endocytosis by the carcinogen lindane involves activation of the ERK/mitogen-activated protein kinase pathway Mograbi, B, Samson, M, Defamie, N, Pointis, G, Corcelle, E, Segretain, D, Fenichel, P, Nebout, M	Carcinogenesis	2003