Reactome | Mevalonate is phosphorylated to mevalonate-5-phosphate

Mevalonate is phosphorylated to mevalonate-5-phosphate

Stable Identifier

R-HSA-191380

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

(R)-mevalonate + ATP => (R)-5-phosphomevalonate + ADP + H(+)

ReviewStatus

5/5

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Mevalonate is phosphorylated to mevalonate-5-phosphate

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Cytosolic mevalonate kinase (MK) catalyzes the phosphorylation of mevalonate (MVA) to mevalonate-5-phosphate (MVA5P) (Hogenboom et al. 2004; Houten & Waterham 2000: Schafer et al. 1992).

Literature References

PubMed ID	Title	Journal	Year
1377680	Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria Schafer, BL, Bishop, RW, Kratunis, VJ, Kalinowski, SS, Mosley, ST, Gibson, KM, Tanaka, RD	J Biol Chem	1992
14730012	Mevalonate kinase is a cytosolic enzyme in humans Hogenboom, S, Tuyp, JJ, Espeel, M, Koster, J, Wanders, RJA, Waterham, HR	J Cell Sci	2004
11111075	Biochemical and genetic aspects of mevalonate kinase and its deficiency Houten, SM, Waterham, HR	Biochim Biophys Acta	2000