Mevalonate is phosphorylated to mevalonate-5-phosphate

Stable Identifier
R-HSA-191380
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Mevalonate is phosphorylated to mevalonate-5-phosphate
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Mevalonate kinase (MK) catalyzes the phosphorylation of mevalonate to mevalonate-5-phosphate.

Literature References
PubMed ID Title Journal Year
1377680 Molecular cloning of human mevalonate kinase and identification of a missense mutation in the genetic disease mevalonic aciduria

Mosley, ST, Bishop, RW, Schafer, BL, Kalinowski, SS, Kratunis, VJ, Gibson, KM, Tanaka, RD

J Biol Chem 1992
14730012 Mevalonate kinase is a cytosolic enzyme in humans

Koster, J, Tuyp, JJ, Wanders, RJA, Espeel, M, Waterham, HR, Hogenboom, S

J Cell Sci 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

mevalonate kinase activity of MVK dimer [cytosol]

Physical Entity
MVK dimer [cytosol] (Homo sapiens)
Activity
mevalonate kinase activity (GO:0004496)
Orthologous Events
Mevalonate is phosphorylated to mevalonate-5-phosphate (Bos taurus)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Caenorhabditis elegans)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Canis familiaris)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Danio rerio)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Dictyostelium discoideum)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Drosophila melanogaster)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Gallus gallus)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Mus musculus)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Rattus norvegicus)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Saccharomyces cerevisiae)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Schizosaccharomyces pombe)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Sus scrofa)
Mevalonate is phosphorylated to mevalonate-5-phosphate (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
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