Reactome | HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

Stable Identifier

R-HSA-191323

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)

ReviewStatus

5/5

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HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

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3-hydroxy-3-methylglutaryl Coenzyme A synthase (HMG-CoA synthase) catalyzes the condensation of acetyl CoA with acetoacetyl CoA to produce HMG-CoA. There are two forms of this enzyme, cytosolic and mitochondrial. The cytosolic form is ubiquitous in the body and is involved in cholesterol biosynthesis and synthesis of other isoprenoid products. The mitochondrial form, found solely in the liver and kidney, is involved in the ketogenic pathway.

Literature References

PubMed ID	Title	Journal	Year
7913309	Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes Rokosz, LL, Boulton, DA, Butkiewicz, EA, Sanyal, G, Cueto, MA, Lachance, PA, Hermes, JD	Arch Biochem Biophys	1994