HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

Stable Identifier
R-HSA-191323
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Condensation of acetyl CoA with acetoacetyl CoA to form HMG-CoA
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3-hydroxy-3-methylglutaryl Coenzyme A synthase (HMG-CoA synthase) catalyzes the condensation of acetyl CoA with acetoacetyl CoA to produce HMG-CoA. There are two forms of this enzyme, cytosolic and mitochondrial. The cytosolic form is ubiquitous in the body and is involved in cholesterol biosynthesis and synthesis of other isoprenoid products. The mitochondrial form, found solely in the liver and kidney, is involved in the ketogenic pathway.

Literature References
PubMed ID Title Journal Year
7913309 Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes

Rokosz, LL, Boulton, DA, Butkiewicz, EA, Sanyal, G, Cueto, MA, Lachance, PA, Hermes, JD

Arch Biochem Biophys 1994
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hydroxymethylglutaryl-CoA synthase activity of HMGCS1 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created