HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA

Stable Identifier
R-HSA-191323
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
acetoacetyl-CoA + acetyl-CoA + H2O => (3S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)
ReviewStatus
5/5
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HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA
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The cytosolic form of 3-hydroxy-3-methylglutaryl Coenzyme A synthase (HMGCS1) catalyzes the condensation of acetyl CoA with acetoacetyl CoA to produce HMG-CoA. HMGCS1 is ubiquitously expressed in the body and is involved in synthesis of isoprenoids and cholesterol biosynthesis (Rokosz et al. 1994).
Literature References
PubMed ID Title Journal Year
7913309 Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes

Rokosz, LL, Boulton, DA, Butkiewicz, EA, Sanyal, G, Cueto, MA, Lachance, PA, Hermes, JD

Arch Biochem Biophys 1994
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Catalyst Activity

hydroxymethylglutaryl-CoA synthase activity of HMGCS1 [cytosol]

Physical Entity
HMGCS1 [cytosol] (Homo sapiens)
Activity
hydroxymethylglutaryl-CoA synthase activity (GO:0004421)
Orthologous Events
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Bos taurus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Caenorhabditis elegans)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Canis familiaris)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Dictyostelium discoideum)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Drosophila melanogaster)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Gallus gallus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Mus musculus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Rattus norvegicus)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Saccharomyces cerevisiae)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Schizosaccharomyces pombe)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Sus scrofa)
HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA (Xenopus tropicalis)
Cross References
RHEA
Authored
Jassal, B  (2007-01-24)
Reviewed
D'Eustachio, P  (2007-01-22)
Created
Jassal, B  (2007-01-19)
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