NICD1 binds HIF1A

Stable Identifier
R-HSA-1912396
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NICD1 binds HIF1A
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When the oxygen supply is low, hypoxia-inducible factor 1-alpha (HIF1A) accumulates in the nucleus where it binds and prolongs the half-life of NICD1, resulting in increased NICD1-mediated transcription and consequent inhibition of cellular differentiation.

Literature References
PubMed ID Title Journal Year
16256737 Hypoxia requires notch signaling to maintain the undifferentiated cell state

Poellinger, L, Ruas, JL, Jin, S, Pereira, T, Bondesson, M, Zheng, X, Lendahl, U, Lundkvist, J, Gradin, K, Gustafsson, MV

Dev Cell 2005
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Input
Output
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as an event of
Inferred From
mNICD1 binds HIF1A (Homo sapiens)
Authored
Orlic-Milacic, M  (2011-11-14)
Egan, SE  (2011-11-14)
Reviewed
Haw, R  (2012-02-06)
Created
Orlic-Milacic, M  (2011-11-02)
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