ALAD binds to Pb2+

Stable Identifier
R-HSA-190141
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ALAD octamer associates with Pb++, forming a catalytically inactive complex
ReviewStatus
5/5
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ALAD binds to Pb2+
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Lead binds to ALAD enzyme displacing half the zinc ions essential for its catalytic activity and inactivating it. Lead is a major environmental toxin and this enzyme is one of its principal molecular targets (Jaffe et al. 2001).
Literature References
PubMed ID Title Journal Year
11032836 The molecular mechanism of lead inhibition of human porphobilinogen synthase

Jaffe, EK, Martins, J, Li, J, Kervinen, J, Dunbrack RL, Jr

J Biol Chem 2001
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Catalyst Activity

lead ion binding activity of ALAD [cytosol]

Physical Entity
ALAD [cytosol] (Homo sapiens)
Activity
lead ion binding (GO:0032791)
Disease
Name Identifier Synonyms
disease DOID:4
Cross References
Mondo
Authored
Jassal, B  (2007-01-24)
D'Eustachio, P  (2007-01-24)
Reviewed
Sassa, S  (2007-01-24)
Hill, DP  (2024-02-16)
Hill, DP  (2025-08-13)
Created
Jassal, B  (2006-12-18)
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