Reactome | ALAD binds to Pb2+

ALAD binds to Pb2+

Stable Identifier

R-HSA-190141

Type

Reaction

Species

Homo sapiens

Compartment

cytosol

Synonyms

ALAD octamer associates with Pb++, forming a catalytically inactive complex

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Lead binds to ALAD enzyme displacing half the zinc ions essential for its catalytic activity and inactivating it. Lead is a major environmental toxin and this enzyme is one of its principal molecular targets (Jaffe et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
11032836	The molecular mechanism of lead inhibition of human porphobilinogen synthase Martins, J, Dunbrack RL, Jr, Kervinen, J, Li, J, Jaffe, EK	J Biol Chem	2001