BLVRA:Zn2+, BLVRB reduce BV to BIL

Stable Identifier
R-HSA-189384
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Bilirubin (BIL) is the breakdown product of heme, causing death if allowed to accumulate in the blood. It is highly lipophilic and requires conjugation to become more water soluble to aid excretion. BIL is formed from the reduction of biliverdin (BV) by bilverdin reductases BLVRA and BLVRB (Cunningham et al. 2000, Fu et al. 2012, O'Brien et al. 2015).

Literature References
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Participates
Catalyst Activity

biliverdin reductase (NAD(P)+) activity of BLVRA:Zn2+,BLVRB [cytosol]

Orthologous Events
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