BLVRA:Zn2+, BLVRB reduce BV to BIL

Stable Identifier
R-HSA-189384
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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BLVRA:Zn2+, BLVRB reduce BV to BIL
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Bilirubin (BIL) is the breakdown product of heme, causing death if allowed to accumulate in the blood. It is highly lipophilic and requires conjugation to become more water soluble to aid excretion. BIL is formed from the reduction of biliverdin (BV) by bilverdin reductases BLVRA and BLVRB (Cunningham et al. 2000, Fu et al. 2012, O'Brien et al. 2015).
Literature References
Participants
Input
Output
Participates
as an event of
Catalyst Activity

biliverdin reductase [NAD(P)+] activity of BLVRA:Zn2+,BLVRB [cytosol]

Physical Entity
BLVRA:Zn2+,BLVRB [cytosol] (Homo sapiens)
Activity
biliverdin reductase [NAD(P)+] activity (GO:0004074)
Orthologous Events
BLVRA:Zn2+, BLVRB reduce BV to BIL (Bos taurus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Canis familiaris)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Danio rerio)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Drosophila melanogaster)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Gallus gallus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Mus musculus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Rattus norvegicus)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Sus scrofa)
BLVRA:Zn2+, BLVRB reduce BV to BIL (Xenopus tropicalis)
Cross References
Rhea
Authored
Jassal, B  (2006-11-20)
Reviewed
Somers, J  (2021-01-23)
Sassa, S  (2007-01-24)
Created
Jassal, B  (2006-11-20)
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