SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region

Stable Identifier
R-HSA-189242
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
cytosolic fructose, galactose, or glucose => extracellular fructose, galactose, or glucose
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The reversible facilitated diffusion of fructose, galactose, and glucose from the cytosol to the extracellular space is mediated by tetrameric SLC2A2 (also known as GLUT2) transporter in the plasma membrane. In the epithelial cells of the small intestine, the basolateral localization of SLC2A2 (Thorens et al. 1990) enables hexose sugars derived from the diet and taken up by the action of the SLC5A1 (SGLT1) and SLC2A5 (GLUT5) transporters to be released into the circulation. The specificity of the SLC2A2 transporter has been established directly through biochemical assays of purified recombinant proteins (Colville et al. 1993; Wu et al. 1998) and indirectly through studies of patients deficient in SLC2A2 transporter protein (Santer et al. 1997).

Literature References
PubMed ID Title Journal Year
9751501 Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity

Wu, L, Fritz, JD, Powers, AC

Endocrinology 1998
9354798 Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome

Santer, R, Schneppenheim, R, Dombrowski, A, Gotze, H, Steinmann, B, Schaub, J

Nat Genet 1997
1701966 Liver glucose transporter: a basolateral protein in hepatocytes and intestine and kidney cells

Thorens, B, Cheng, ZQ, Brown, D, Lodish, HF

Am J Physiol 1990
8457197 Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors

Colville, CA, Seatter, MJ, Jess, TJ, Gould, GW, Thomas, HM

Biochem J 1993
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
hexose transmembrane transporter activity of GLUT2 / SLC2A2 tetramer [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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