Reactome | SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region

SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region

Stable Identifier

R-HSA-189242

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

cytosolic fructose, galactose, or glucose => extracellular fructose, galactose, or glucose

ReviewStatus

5/5

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SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region

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The reversible facilitated diffusion of fructose, galactose, and glucose from the cytosol to the extracellular space is mediated by tetrameric SLC2A2 (also known as GLUT2) transporter in the plasma membrane. In the epithelial cells of the small intestine, the basolateral localization of SLC2A2 (Thorens et al. 1990) enables hexose sugars derived from the diet and taken up by the action of the SLC5A1 (SGLT1) and SLC2A5 (GLUT5) transporters to be released into the circulation. The specificity of the SLC2A2 transporter has been established directly through biochemical assays of purified recombinant proteins (Colville et al. 1993; Wu et al. 1998) and indirectly through studies of patients deficient in SLC2A2 transporter protein (Santer et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9354798	Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome Santer, R, Schneppenheim, R, Dombrowski, A, Gotze, H, Steinmann, B, Schaub, J	Nat Genet	1997
9751501	Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity Wu, L, Fritz, JD, Powers, AC	Endocrinology	1998
1701966	Liver glucose transporter: a basolateral protein in hepatocytes and intestine and kidney cells Thorens, B, Cheng, ZQ, Brown, D, Lodish, HF	Am J Physiol	1990
8457197	Kinetic analysis of the liver-type (GLUT2) and brain-type (GLUT3) glucose transporters in Xenopus oocytes: substrate specificities and effects of transport inhibitors Colville, CA, Seatter, MJ, Jess, TJ, Gould, GW, Thomas, HM	Biochem J	1993