IP6 is dephosphorylated to I(1,2,4,5,6)P5 by MINPP1 in the ER lumen

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the endoplasmic reticulum (ER) lumen, multiple inositol polyphosphate phosphatase 1 (MINPP1) dephosphorylates 1,2,3,4,5,6-hexakisphosphate (IP6) to inositol 1,2,4,5,6-pentakisphosphate (I(1,2,4,5,6)P5) (Caffrey et al. 1999, Chi et al. 1999, Deleu et al. 2006, Nogimori et al. 1991).

Literature References
PubMed ID Title Journal Year
10087200 Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19

Chi, H, Reynolds, PR, O'keefe, RJ, Romano, PR, Rosier, RN, Wang, J, Tiller, GE, Dasouki, MJ, Puzas, JE

Genomics 1999
1653239 Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity

Hughes, PJ, Hodgson, ME, Putney JW, Jr, Glennon, MC, Shears, SB, Nogimori, K

J Biol Chem 1991
9923613 The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification

Hidaka, K, Matsuda, M, Caffrey, JJ, Hirata, M, Shears, SB

FEBS Lett 1999
15979280 Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P(5) pool

Cho, J, Choi, K, Sulis, ML, Pesesse, X, Parsons, R, Deleu, S, Shears, SB

Cell Signal 2006
Catalyst Activity

inositol hexakisphosphate 2-phosphatase activity of MINPP1 [endoplasmic reticulum lumen]

Orthologous Events
Cross References
Cite Us!