Reactome | Synthesis of IPs in the ER lumen

Synthesis of IPs in the ER lumen

Stable Identifier

R-HSA-1855231

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

In the endoplasmic reticulum (ER) lumen, inositol phosphates IP4, IP5, and IP6 are dephosphorylated by multiple inositol polyphosphate phosphatase 1 (MINPP1) (Caffrey et al. 1999, Chi et al. 1999, Deleu et al. 2006, Nogimori et al. 1991).

Literature References

PubMed ID	Title	Journal	Year
10087200	Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19 Chi, H, Tiller, GE, Dasouki, MJ, Romano, PR, Wang, J, O'keefe, RJ, Puzas, JE, Rosier, RN, Reynolds, PR	Genomics	1999
1653239	Purification of an inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase activity from rat liver and the evaluation of its substrate specificity Nogimori, K, Hughes, PJ, Glennon, MC, Hodgson, ME, Putney JW, Jr, Shears, SB	J Biol Chem	1991
9923613	The human and rat forms of multiple inositol polyphosphate phosphatase: functional homology with a histidine acid phosphatase up-regulated during endochondral ossification Caffrey, JJ, Hidaka, K, Matsuda, M, Hirata, M, Shears, SB	FEBS Lett	1999
15979280	Physiological levels of PTEN control the size of the cellular Ins(1,3,4,5,6)P(5) pool Deleu, S, Choi, K, Pesesse, X, Cho, J, Sulis, ML, Parsons, R, Shears, SB	Cell Signal	2006