CBL binds and ubiquitinates phosphorylated Sprouty

Stable Identifier
R-HSA-183089
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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CBL binds and ubiquitinates phosphorylated Sprouty
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Sprouty is ubiquitinated by CBL in an EGF-dependent manner. EGF stimulation induces the tyrosine phosphorylation of Sprouty, which in turn enhances the interaction of Sprouty with CBL.The CBL-mediated ubiquitination of Sprouty targets the protein for degradation by the 26S proteosome.
Literature References
PubMed ID Title Journal Year
12593796 hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl

Hall, AB, Jura, N, DaSilva, J, Jang, YJ, Gong, D, Bar-Sagi, D

Curr Biol 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane]

Physical Entity
EGF-like ligands:p-6Y-EGFR:p-Y371-CBL [plasma membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
CBL binds and ubiquitinates phosphorylated Sprouty (Bos taurus)
CBL binds and ubiquitinates phosphorylated Sprouty (Canis familiaris)
CBL binds and ubiquitinates phosphorylated Sprouty (Danio rerio)
CBL binds and ubiquitinates phosphorylated Sprouty (Drosophila melanogaster)
CBL binds and ubiquitinates phosphorylated Sprouty (Gallus gallus)
CBL binds and ubiquitinates phosphorylated Sprouty (Mus musculus)
CBL binds and ubiquitinates phosphorylated Sprouty (Rattus norvegicus)
CBL binds and ubiquitinates phosphorylated Sprouty (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-07-21)
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