Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase

Stable Identifier
R-HSA-1793217
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
lysosomal lumen
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Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase
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Keratan sulfate (KS) is cleaved from its KS proteoglycan (KSPG) by an as yet unknown beta-galactosidase. It performs a similar function to beta-galactosidase GLB1 (Asp et al. 1969). A simplified version of KS is used to demonstrate cleavage reactions.

Literature References
PubMed ID Title Journal Year
5822067 Human small-intestinal beta-galactosidases. Separation and characterization of one lactase and one hetero beta-galactosidase

Koldovský, O, Asp, NG, Dahlqvist, A

Biochem J 1969
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Catalyst Activity

beta-galactosidase activity of keratan sulfate 1,4-beta-D-galactosidase [lysosomal lumen]

Physical Entity
keratan sulfate 1,4-beta-D-galactosidase [lysosomal lumen] (Homo sapiens)
Activity
beta-galactosidase activity (GO:0004565)
Authored
Jassal, B  (2011-10-21)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-10-21)
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