Reactome | Expression of ASNS (Asparagine Synthetase)

Expression of ASNS (Asparagine Synthetase)

Stable Identifier

R-HSA-1791118

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, cytosol

ReviewStatus

5/5

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Expression of ASNS (Asparagine Synthetase)

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The Asparagine Synthetase (ASNS) gene is transcribed to yield mRNA and the mRNA is translated to yield protein (Chen et al. 2004, Lee et al. 2008, Gjymishka et al. 2009, Sikalidis et al. 2011, Balasubramanian et al. 2013, inferred from the mouse homolog). Transcription of ASNS is activated by the unfolded protein response (Gjymishka et al. 2009), amino acid deficiency (Chen et al. 2004, Lee et al. 2008, Sikalidis et al. 2011, Balasubramanian et al. 2013, inferred from the mouse homolog), and heme deficiency (inferred from the mouse homolog).

Literature References

PubMed ID	Title	Journal	Year
18285520	HepG2/C3A cells respond to cysteine deprivation by induction of the amino acid deprivation/integrated stress response pathway Lee, JI, Dominy, JE, Sikalidis, AK, Hirschberger, LL, Wang, W, Stipanuk, MH	Physiol. Genomics	2008
20361218	Gene expression and integrated stress response in HepG2/C3A cells cultured in amino acid deficient medium Sikalidis, AK, Lee, JI, Stipanuk, MH	Amino Acids	2011
15385533	Amino acid deprivation induces the transcription rate of the human asparagine synthetase gene through a timed program of expression and promoter binding of nutrient-responsive basic region/leucine zipper transcription factors as well as localized histone acetylation Chen, H, Pan, YX, Dudenhausen, EE, Kilberg, MS	J. Biol. Chem.	2004
22978410	Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation Balasubramanian, MN, Shan, J, Kilberg, MS	Biochem. J.	2013
18840095	Transcriptional induction of the human asparagine synthetase gene during the unfolded protein response does not require the ATF6 and IRE1/XBP1 arms of the pathway Gjymishka, A, Su, N, Kilberg, MS	Biochem J	2009

Participants

Input

ASNS gene [nucleoplasm] (Homo sapiens)

Output

ASNS [cytosol] (Homo sapiens)

Participates

as an event of

This event is regulated

Positively by

Regulator

ATF4:CEBPB,CEBPG:ASNS gene [nucleoplasm] (Homo sapiens)

Inferred From

Expression of Asns (Mus musculus)

Authored

May, B (2011-10-13)

Reviewed

D'Eustachio, P (2008-12-02)

Matthews, L (2008-12-02)

Gillespie, ME (2008-12-02)

Urano, F (2010-04-30)

Bruhat, A (2019-09-15)

Chen, JJ (2019-10-22)

Staschke, KA (2019-11-20)

Created

May, B (2011-10-21)