Binding of PIK3 regulatory alpha subunit to GRB2:GAB1

Stable Identifier
R-HSA-177931
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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Binding of PIK3 regulatory alpha subunit to GRB2:GAB1
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The Src homology 2 (SH2) domain of the phosphatidylinositol 3-kinase (PIK3) regulatory subunit (PIK3R1, i.e. PI3Kp85) binds to GAB1 in a phosphorylation-independent manner. GAB1 serves as a docking protein which recruits a number of downstream signalling proteins. PIK3R1 can bind to either GAB1 or phosphorylated GAB1.

Literature References
PubMed ID Title Journal Year
11606067 Unique phosphorylation mechanism of Gab1 using PI 3-kinase as an adaptor protein

Fukushima, Y, Inukai, K, Kikuchi, M, Ogihara, T, Onishi-Haraikawa, Y, Asano, T, Funaki, M, Sakoda, H, Anai, M, Katagiri, H, Shibuya, M, Gotoh, N, Oka, Y, Ono, H

Biochem Biophys Res Commun 2001
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Orthologous Events
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Caenorhabditis elegans)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Canis familiaris)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Danio rerio)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Drosophila melanogaster)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Gallus gallus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Mus musculus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Rattus norvegicus)
Binding of PIK3 regulatory alpha subunit to GRB2:GAB1 (Sus scrofa)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
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