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viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6
Stable Identifier
R-HSA-450309
Type
Complex
Species
Homo sapiens
Related Species
Rotavirus,
Influenza A virus,
Hepatitis B virus,
Hepatitis C Virus,
Human herpesvirus 1
Compartment
endosome membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-Like Receptors Cascades (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
TICAM1,TRAF6-dependent induction of TAK1 complex (Homo sapiens)
Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
Activation of recruited TAK1 within the activated TLR3 complex (Homo sapiens)
viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
Phosphorylated TAK1 dissociates from the TLR3 receptor complex (Homo sapiens)
viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF(TICAM1)-mediated TLR4 signaling (Homo sapiens)
TRAF6-mediated induction of TAK1 complex within TLR4 complex (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation (Homo sapiens)
K63-linked polyUb TRAF6 complexes [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1:K63pUb-TRAF6 [endosome membrane] (Homo sapiens)
Participants
components
K63polyUb-TRAF6 [endosome membrane] (Homo sapiens)
viral dsRNA:TLR3:TICAM1 [endosome membrane] (Homo sapiens)
Participant Of
input
Activated TLR3:TRIF:K63pUb-TRAF6 recruits TAK1complex
hasMember
K63-linked polyUb TRAF6 complexes [endosome membrane]
hasComponent
viral dsRNA:TLR3:TRIF:polyUb-TRAF6:TAK1:TAB1:TAB2/TAB3: free polyUb chain [endosome membrane]
viral dsRNA:TLR3:TRIF:pUb-TRAF6:TAB1:TAB2,TAB3:free polyUb: p-TAK1 [endosome membrane]
output
Auto ubiqitination of TRAF6 bound to viral dsRNS:TLR3:TICAM1 complex
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