Rad9-Hus1-Rad1 bound to DNA [nucleoplasm]

Stable Identifier
R-HSA-176256
Type
Complex
Species
Homo sapiens
Compartment
nucleoplasm
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General
A major known function of the 9-1-1 complex is to recruit Chk1 to stalled replication forks for activation by ATR. However, the presence of the 9-1-1 complex also alters the ability of Rad17 to become phoshorylated, perhaps suggesting that 9-1-1 may also serve to recruit a subset of ATR substrates. The 9-1-1 complex has also been found to interact with base excision repair factors human DNA polymerase beta, flap endonuclease FEN1, and the S. pombe MutY homolog (SpMYH), indicating that 9-1-1 also plays a direct role in DNA repair.
Participants
components
Participates
as an output of
Inferred To
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Bos taurus)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Caenorhabditis elegans)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Canis familiaris)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Dictyostelium discoideum)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Drosophila melanogaster)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Gallus gallus)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Mus musculus)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Rattus norvegicus)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Saccharomyces cerevisiae)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Schizosaccharomyces pombe)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Sus scrofa)
Rad9-Hus1-Rad1 bound to DNA [nucleoplasm] (Xenopus tropicalis)
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